Tan et al are to be congratulated for achieving the difficult task of synthesizing the many disparate pieces of data on the subject of exchange transfusion (ET) [1]. However, we believe their conclusion that “adjunct ET cannot be recommended” should have been qualified with an acknowledgment that they have shown a “lack of evidence for benefit” rather than “evidence for lack of benefit.” The re...

In this issue of Indian Pediatrics, Shahian and Moslehi(1) report that albumin given prior to exchange transfusion in jaundiced but healthy term newborns is associated with significantly lower post-procedure total serum unconjugated bilirubin levels (TSB) and a reduced need for further treatment. Unfortunately, the evidence presented does not support routine administration of albumin prior to e...

Before 1941, erythroblastosis foetalis was treated at Birmingham Maternity Hospital by repeated intramuscular injections of fresh blood (Braid, 1939). During the next decade infants with Rh haemolytic disease of the newborn were given repeated intravenous transfusions of Rh negative blood. The exchange transfusion was not introduced until 1950. The first three years' experience (1950-53) with t...

Changes in mean arterial pressure were monitored in rats following 50% isovolemic exchange transfusion with solutions of chemically modified hemoglobins. Blood pressure responses fall into three categories: 1) an immediate and sustained increase, 2) an immediate yet transient increase, or 3) no significant change either during or subsequent to exchange transfusion. The reactivities of these hem...

background and objective: patients with thalassemia major have an abnormality in hemoglobin synthesis and ineffective hematopoiesis and for this reason with respect to disease severity should receive one or more fresh blood unit every 15-30 days. since transfusion of blood products has been known as one of the routes of hiv infection, therefore, this study was conducted to evaluate the prevalen...

conclusions: hydroxyurea can be safely used in some transfusion-dependent β-thalassemia patients to decrease their transfusion needs. background: β-thalassemia is an inherited hemoglobin disorder caused by defective synthesis of ß-globin chains. hemoglobin (hb) f induction is a possible therapeutic approach which can partially compensate for α and non-α globin chains imbalance. objectives: we a...

transfusion of blood and its components/derivatives is a life saving medical intervention. however, this life saving procedure depends mainly on the availability of sufficient blood and its components in national health sector. therefore the overall safety of transfusion medicines including the safety of blood and its available components and the appropriate use of these components would direct...

Exchange Transfusion Key Points..............................................2 Preparation of Infant.................................................................3 Calculation of Volume for Exchange...........................................3 Procedure Techniques..............................................................4 Isovolumetric Method Set-Up...........................................