the interpretation of supernumerary chromosome is important for genetic counseling and prognosis. here, we used snp array and conventional karyotyping method to identify a denovo marker chromosome originated from chromosome 22 and 11 in a newborn transferred to the neonatal intensive care unit of shahid sadoughi hospital in 2015.  clinical abnormalities identified in the newborn were dysmorphic...

This paper examines the generalization properties of online convex programming algorithms when the loss function is Lipschitz and strongly convex. Our main result is a sharp bound, that holds with high probability, on the excess risk of the output of an online algorithm in terms of the average regret. This allows one to use recent algorithms with logarithmic cumulative regret guarantees to achi...

there are miscellaneous quality characteristics in healthcare which are interested to be monitored. however, monitoring each characteristic needs a special statistical method. there are some characteristics with very small incidence rates that it’s usually considered not to be necessary to monitoring them, since their incidence rates are so small that p and np charts are not able to monitor the...

Sex chromosome evolution is usually seen as a process that, once initiated, will inevitably progress toward an advanced stage of degeneration of the nonrecombining chromosome. However, despite evidence that avian sex chromosome evolution was initiated >100 Ma, ratite birds have been trapped in an arrested stage of sex chromosome divergence. We performed RNA sequencing of several tissues from ma...

Inactivation of the X chromosome in the male germ line has been suggested to contribute to the excess of gene movement off the X chromosome and the paucity of X-linked male-biased genes that have been observed in Drosophila species. Recent experimental work has demonstrated the transcriptional inactivation of the X chromosome during spermatogenesis, but it is not known if some regions of the X ...