Ewing sarcoma is an aggressive cancer of bone and soft tissue in children with poor prognosis. It is characterized by the chromosomal translocation between EWS and an Ets family transcription factor, most commonly FLI-1. EWS-FLI-1 fusion accounts for 85% of Ewing sarcoma cases. EWS-FLI-1 regulates the expression of a number of genes important for sarcomagenesis, can transform NIH3T3 and C3H10T1...

OBJECTIVES A review is made of the clinical, diagnostic, therapeutic and survival characteristics of Ewing sarcoma (ES) of the oral cavity. MATERIAL AND METHODS A systematic literature search was carried out, with restrictions referred to time (1960-2014), language (English and Spanish) and type of study (case reports, letters, datasets, reviews). The following MeSH terms and boolean operator...

1. department of pathology, burdwan medical college, burdwan, west bengal, india 2. department of pathology, bankura sammilani medical college, bankura, west bengal, india                   corresponding author: nirmalya chakrabarti, md; tel: (+91) 9477882332 email: [email protected] received: 06 july 2014 accepted: 03 feb. 2015 iran j cancer prev. 2015; 2:129-33.     abstract among...

primary bone tumors are the sixth most common neoplasm occurring in children and constitute approximately 6% of all childhood malignancies with a peak incidence in 15- to 19-year- old individuals. these lesions are the third most common tumors in adolescents and young adults (exceeded only by leukemia and lymphoma) common complaints are intermittent to constant mild to severe pain, constitution...

PURPOSE The goal of this study is to optimize the activity of trabectedin for Ewing sarcoma by developing a molecularly targeted combination therapy. EXPERIMENTAL DESIGN We have recently shown that trabectedin interferes with the activity of EWS-FLI1 in Ewing sarcoma cells. In this report, we build on this work to develop a trabectedin-based combination therapy with improved EWS-FLI1 suppress...

UNLABELLED Ewing sarcoma is the second most common bone cancer in pediatric patients. Although the primary cause of death in Ewing sarcoma is metastasis, the mechanism underlying tumor spread needs to be elucidated. To this end, the role of the CXCR4/SDF-1a chemokine axis as a mediator of Ewing sarcoma metastasis was investigated. CXCR4 expression status was measured in primary tumor specimens ...

abstract background ewing sarcoma is the second most frequent primary bone cancer, following osteosarcoma in children. these tumors consist of small, round, or oval cells, which are believed to derive from parasympathetic autonomic nervous system. the common clinical presentations are pain, local tenderness, fever, palpable mass, and pathologic fractures. methods and materials this study descri...

background: ewing sarcoma family of tumors (esfts) is the second most common primary tumors of bone in childhood. the decision regarding the optimal modality for achieving local tumor control remains uncertain. the aim of this study was to report the clinical features and outcome as well as reviewing risk factors in patients. materials and methods: this retrospective study included 75 esfts pat...

MicroRNAs (miRs) have emerged recently as important regulators of gene expression in the cell. Frequently dysregulated in cancer, miRs have shed new light on molecular mechanisms of oncogenesis, and have generated substantial interest as biomarkers, and novel therapeutic agents and targets. Recently, a number of studies have examined miR biology in Ewing sarcoma. Findings indicate that alterati...

Ewing sarcomas are the second most common primary malignant bone tumors in childhood and adolescence which rapidly metastasize. Due to improvement of treatment options in recent years, the survival rate has significantly increased. Nevertheless, lethality is still high, and neurologic symptoms are frequent. To the best of our knowledge, this is the first reported case of a sacral osteoneogenesi...