The Agency for Healthcare Research and Quality (AHRQ), through its Evidencebased Practice Centers (EPCs), sponsors the development of evidence reports and technology assessments to assist publicand private-sector organizations in their efforts to improve the quality of health care in the United States. The reports and assessments provide organizations with comprehensive, science-based informati...

Pharmacokinetics is a fundamental scientific discipline that underpins applied therapeutics. Patients need to be prescribed appropriate medicines for a clinical condition. The medicine is chosen on the basis of an evidencebased approach to clinical practice and assured to be compatible with any other medicines or alternative therapies the patient may be taking. The design of a dosage regimen is...

In clinical practice, physicians often use certain strategies based on guidelines or recommendations from experts. This is because in the era of evidencebased medicine, clinicians are more willing to make “evidence-based” decisions. This is also the case in the field of lipid-lowering therapy. The term “lipidlowering therapy” does not simply refer to items with abnormal values in the lipid prof...

AIM The overall aim of this project was to develop an evidencebased clinical practice guideline for evaluation and management of CKD. The guideline consists of recommendation statements, rationales, and a summary of systematically generated evidence on relevant pre-defined clinical topics. To a large extent the guideline builds on the output of the KDIGO Controversies Conference in 2009, which ...

The Agency for Healthcare Research and Quality (AHRQ), through its Evidencebased Practice Centers (EPCs), sponsors the development of evidence reports and technology assessments to assist publicand private-sector organizations in their efforts to improve the quality of health care in the United States. The reports and assessments provide organizations with comprehensive, science-based informati...

SEE PAGE 126 T he hallmark of ST-segment elevation myocardial infarction (STEMI) is thrombotic occlusion of an epicardial vessel. As many as 50% of patients undergoing primary percutaneous coronary intervention (PCI) demonstrate distal embolization and microvascular obstruction despite achieving normalized epicardial flow. This is associated with increased infarct size, reduced recovery of vent...

During the brief time that we have been engaged in developing Evidence-Based Nursing we have been fascinated by the reactions of friends, professional colleagues, and the media. The overwhelming majority of responses to the concepts of evidence-based nursing and the creation of this journal have been positive. But there have also been misgivings, sometimes generated by misunderstandings. This e...

In most of the large companies IT project prioritization process is designed based on principles of evidencebased management. We investigate a case of IT project prioritization in a financial institution, and in particular, how managers practice evidence-based management during this process. We use a rich dataset built from a longitudinal study of the prioritization process for the IT projects....

With the development of specialized nutrition support, an interdisciplinary approach was essential to translating this medical breakthrough from the laboratory to the bedside. As this new innovation was adopted, interdisciplinary nutrition support teams were created to optimize the effectiveness and safety of this therapy. The impact of standardization and the use of an interdisciplinary team t...

The Agency for Healthcare Research and Quality (AHRQ), through its Evidencebased Practice Centers (EPCs), sponsors the development of evidence reports and technology assessments to assist publicand private-sector organizations in their efforts to improve the quality of health care in the United States. The reports and assessments provide organizations with comprehensive, science-based informati...