BACKGROUND For the large population of elderly patients with cardiovascular disease, it is crucial to identify clinically relevant measures of biological age and their contribution to risk. Frailty is denoting decreased physiological reserves and increased vulnerability. We analysed the manner in which the variable frailty is associated with 1-year outcomes for elderly non-ST-segment elevation ...

BACKGROUND AND OBJECTIVES Uromodulin-associated kidney disease (UAKD) is an autosomal dominant disease caused by uromodulin (UMOD) gene mutations. This study explored genotype-phenotype correlations by examining the relationship between the type of UMOD mutation and the age at onset of ESRD. DESIGN, SETTING, PARTICIPANTS & MEASUREMENTS Extensive bibliographic research was used to ascertain pa...

The study’s objective was to examine the health status, physical activity behaviors, and performance-based functional abilities of individuals classified as being at high or low risk for frailty and to determine which of these characteristics discriminates between the 2 groups. Participants were 78 community-dwelling individuals with an average age of 74 years; 37 were categorized as being at h...

Basic Problem: Heterogeneity What is it? Usually thought of as unmeasured risk factors. Can be induced when a relevant covariate is not included in the model’s specification. Maybe these factors are not measured (unmeasureable?) or are unknown to exist. Heterogeneity can lead to trouble insofar as parameter estimates can be inconsistent, standard errors can be wrong, and estimates of duration d...

BACKGROUND The gamma-Gompertz model is a fixed frailty model in which baseline mortality increases exponentially with age, frailty has a proportional effect on mortality, and frailty at birth follows a gamma distribution. Mortality selects against the more frail, so the marginal mortality rate decelerates, eventually reaching an asymptote. The gammaGompertz is one of a wider class of frailty mo...

abstract background: identify talented people to donate predisposed a major role in supplying healthy blood. if the time interval between donations decrease, the chance that voluntary of blood donation be a regular donor increase. the aim of this study was to determine factors affecting the interval between blood donations in a sample of first-time blood donors. methods: data of a cross-section...

BACKGROUND A high percentage of individuals treated in specialized acute care wards are frail and elderly. Our aim was to study whether the acute care of such patients in a comprehensive geriatric assessment (CGA) unit is superior to care in a conventional acute medical care unit when it comes to activities of daily living (ADLs), frailty, and use of municipal help services. PATIENTS AND METH...

BACKGROUND There is little certainty as to the prevalence of frailty in Canadians in younger adulthood. This study examines and compares the prevalence of frailty in Canadians 18-79 years old using the Accumulation of Deficits and Fried models of frailty. METHODS The Canadian Health Measures Study data were used to estimate the prevalence of frailty in adults 18-79 years old. A 23-item Frailt...

BACKGROUND Frailty prevalence differs across countries depending on the models used to assess it that are based on various conceptual and operational definitions. This study aims to assess the clinical validity of three frailty models among community-dwelling older adults in north-western Russia where there is a higher incidence of cardiovascular disease and lower life expectancy than in Europe...