The seed oil of Euphorbia lathyris L. contains a series of macrocyclic diterpenoids known as Euphorbia factors. They are the current industrial source of ingenol mebutate, which is approved for the treatment of actinic keratosis, a precancerous skin condition. Here, we report an alcohol dehydrogenase-mediated cyclization step in the biosynthetic pathway of Euphorbia factors, illustrating the or...

Protein hydrolysates prepared from a number of medicinal plants are promising sources of various bioactive peptides. In this work, proteins from dried whole plant of Euphorbia hirta Linn. were extracted and digested with pepsin for 12h. The hydrolysates of lesser than 3 KDa were fractionated by a cut-off membrane. The peptide hydrolysate was then purified by an anionexchange chromatography on D...

Infectious diseases, particularly skin and mucosal infections, are common in most of the tribal inhabitants due to lack of sanitation, potable water and awareness of hygienic food habits. Skin diseases like wounds, furuncles, sepsis, atopic dermatitis, cellulitis, gas gangrene, acne, candidiasis can be caused by a variety of the microbes. Plants produce a diverse range of bioactive molecules, m...

Shilajit, exuding from the rocks of mountains has been proved to be basically derived from the latex of cactus like Euphorbia species. Therefore, in the present communication, an attempt has been made to provide similar information from the ayurvedic literatures.

Integrated pest management (IPM) for invasive plant species is being advocated by researchers and implemented by land managers, but few studies have evaluated the success of IPM programs in natural areas. We assessed the relative effects of components of an IPM program for leafy spurge (Euphorbia esula), an invasive plant, at Theodore Roosevelt National Park, North Dakota. Effects of herbicides...

Plants of the genus Euphorbia have been investigated for different bioactive natural products. I have isolated several new and bioactive diterpenoids from different species of Euphorbia of Iran with myrsinane type skeleton. The structure of the compounds was determined using high resolution mass spectroscopy, 1 D and 2 D NMR spectral data. The stereochemistry of the diterpenoids was determined ...

This article explores the ways in which risk and responsibility were conceptualised in the late nineteenth and early twentieth centuries by surgeons, their patients and the lay public. By this point surgery could be seen, simultaneously, as safe (due to developments in surgical science) and increasingly risky (because such progress allowed for greater experimentation). With the glorification of...