In this study we investigated the structure-activity relationships by using the Electron- Topological Method (ETM) for a class of AChE inhibitors related to tacrine (9-amino-1,2,3,4-tetrahydroacridine) and 11 H-Indeno-[1,2-b]-quinolin-10-ylamine that tetracyclic tacrine analogues, a drug currently in use for the treatment of the AD. Molecular fragments being specific for active and inactive com...

The Landsat 7 Enhanced Thematic Mapper Plus (ETM+) scan line corrector (SLC) failed on May 31, 2003, causing the scanning pattern to exhibit wedge-shaped scan-to-scan gaps. The ETM+ has continued to acquire data with the SLC powered off, leading to images that are missing approximately 22 percent of the normal scene area. To improve the utility of the SLC-off data, the U.S. Geological Survey (U...