BACKGROUND Tetracarpidium conophorum (Mull. Arg.) Hutch. & Dalz is one of the many medicinal plants used for ages in folklore as male fertility enhancers. The current study evaluates the effect of the plant leaf extract on alcohol - induced reproductive toxicity in male rats. METHODS Thirty rats were randomly divided into six groups of five animals each; Group 1 (positive control) received no...

Brine shrimp (Artemia salina) cytotoxicity assays (BSLT) are one of the commonly used cytotoxic test methods to assess a plant extract's pharmacological activity and toxicity. Thus, this study aimed examine toxic levels Kecubung (Datura metel) leaves extracted using different solvents, namely ethanol ethyl acetate. The results showed that LC50 value flower ethanol, acetate, leaf stem acetate ex...

 Hepatocellular carcinoma (HCC) is one of the most common malignant tumours in Hong Kong.  Percutaneous ethanol injection (PEI) is an established technique of imaging guided regional therapy for small HCC. In this treatment, absolute ethanol (alcohol) is injected via a small needle into the tumour in an attempt to kill the tumour cells.  The total amount of ethanol injected depends mainly on...

The present study was undertaken to elucidate the effect of ascorbic acid on alcohol-induced reproductive toxicity and also to compare it with that of abstention. A total of thirty-six male guinea pigs were divided into two groups and were maintained for 90 d as control and ethanol-treated groups (4 g/kg body weight (b.wt.)). After 90 d, ethanol administration was stopped and animals in the con...

The practical application of commercial malolactic starter cultures of Oenococcus oeni surviving direct inoculation in wine requires insight into mechanisms of ethanol toxicity and of acquired ethanol tolerance in this organism. Therefore, the site-specific location of proteins involved in ethanol adaptation, including cytoplasmic, membrane-associated, and integral membrane proteins, was invest...

The aim of the study was to determine whether fatty acid ethyl esters, nonoxidative products of ethanol metabolism selectively present in organs damaged by ethanol abuse, are detectable in the serum after ethanol ingestion. Serum samples of hospital emergency room patients with positive (n = 32) and negative (n = 5) blood ethanol levels were assayed for fatty acid ethyl esters. In a separate st...

SnO2 is widely used for ethanol-sensing applications due to its excellent physicochemical properties, low toxicity and high sensitivity. However it a challenge construct 3D-hierarchical structures with sub 5 nm primary grain particle, which the optimized size ethanol sensor. Herein, genetic tri-level hierarchical microstructures are synthesised by conversion of 3D SnS2 flowers assembled ultrath...

The stress imposed by ethanol to Saccharomyces cerevisiae cells are one of the most challenging limiting factors in industrial fuel production. Consequently, toxicity and tolerance high concentrations has been subject extensive research, allowing identification several genes important for increasing this factor. However, studies were performed with well-characterized laboratory strains, how res...

Cyanobacteria have been engineered to produce ethanol through recent synthetic biology efforts. However, one major challenge to the cyanobacterial systems for high-efficiency ethanol production is their low tolerance to the ethanol toxicity. With a major goal to identify novel transporters involved in ethanol tolerance, we constructed gene knockout mutants for 58 transporter-encoding genes of S...

Objective. To study the content of reduced glutathione (GSH), activities peroxidase (GP) and glutathione-S-transferase enzymes (GST) in blood liver rats exposed to subacute alcohol intoxication, its combination with caffeine intake or constant light exposure, possibility their correction melatonin.Materials methods. Experiments were performed on 42 male weighing 180-200 g kept under standard co...