Mutations in wild-type p53 (wtp53) protein lead to loss of its tumor suppressor function in breast cancer cells, facilitating uncontrolled tumor growth. Consequently, procedures to repair defective p53 functions in tumor cells are being actively pursued. We sought to determine whether expression of wtp53 protein, or conversion of endogenous mutant p53 (mtp53) into a functional p53 protein with ...

BACKGROUND Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer death in men. Estrogen induction of cell proliferation is a crucial step in carcinogenesis of gynecologic target tissues, and there are many studies recently done, showing that prostate cancer growth is also influenced by estrogen. The characterization of estrogen receptor beta (ER-b) ...

background and objective: breast cancer is the commonest cancer of indian women. estrogen and progesterone expression is seen in benign breast lesions and in breast carcinoma associated with good prognostic parameters and it correlates well with response to hormone therapy. although a lot of studies have been conducted in the past on hormone receptor expression in breast cancer and few have cor...

the hippocampal system plays an important role in memory function. neurohormones like androgens and estrogens that syntheses in hippocampus have an important role in learning and memory. many biological effects of estrogens in the brain via estrogenic receptors (ers) are investigated. the current research has conducted to assess the effect of estrogenic receptors on spatial discrimination in ra...

background: phytoestrogens, a group of plant-derived polyphenolic compounds have recently come into considerable attention due to the increasing information on their potential adverse effects in human health. some of phytoestrogens show estrogenic activity that may be carcinogenic for human. in the present study, we investigated the transcriptional effects of variety of phytoestrogens on the bo...