نتایج جستجو برای: esr1 gene

تعداد نتایج: 1141824  

Journal: :Genetics and molecular research : GMR 2015
Y H Lee G G Song

The aim of this study was to explore whether estrogen receptor 1 (ESR1) PvuII and XbaI polymorphisms are associated with susceptibility to Alzheimer's disease (AD). We conducted a meta-analysis of the associations between AD and ESR1 PvuII and XbaI polymorphisms as well as haplotypes of the ESR1 PvuII and XbaI polymorphisms. A total of 1359 patients and 1387 controls from 9 studies on the ESR1 ...

2014
Jen-Hwey Chiu Chun-Ju Chang Jing-Chong Wu Hui-Ju Liu Che-Sheng Wen Chung-Hua Hsu Jiun-Liang Chen Ling-Ming Tseng Wei-Shone Chen Yi-Ming Shyr

Aim. Our aim the was to screen the commonly used Chinese herbs in order to detect changes in ERBB2 and ESR1 gene expression using MCF-7 cells. Methods. Using the MCF-7 human breast cancer cell line, cell cytotoxicity and proliferation were evaluated by MTT and trypan blue exclusion assays, respectively. A luciferase reporter assay was established by transient transfecting MCF-7 cells with plasm...

2011
Huong Thi Thanh Tran Hee Nam Kim Il-Kwon Lee Yeo-Kyeoung Kim Jae-Sook Ahn Deok-Hwan Yang Je-Jung Lee Hyeoung-Joon Kim

DNA methyltransferase inhibitor, 5-azacitidine (AC) is effective in myelodysplastic syndromes (MDS) and can induce re-expression in cancer. We analyzed the methylation of 25 tumor suppressor genes in AC-treated MDS. Hypermethylation of CDKN2B, FHIT, ESR1, and IGSF4 gene was detected in 9/44 patients. In concordance with the clinical response, a lack of or decreased methylation in 4 patients wit...

Journal: :Annals of oncology : official journal of the European Society for Medical Oncology 2012
B Ejlertsen J Aldridge K V Nielsen M M Regan K L Henriksen A E Lykkesfeldt S Müller R D Gelber K N Price B B Rasmussen G Viale H Mouridsen

BACKGROUND Estrogen Receptor 1 (ESR1) aberrations may be associated with expression of estrogen receptor (ER) or progesterone receptor (PgR), human epidermal growth factor receptor-2 (HER2) or Ki-67 labeling index and prognosis. PATIENTS AND METHODS ESR1 was assessed in 1129 (81%) of 1396 postmenopausal Danish women with early breast cancer randomly assigned to receive 5 years of letrozole, t...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2015
Rachel Y Cheong Katja Czieselsky Robert Porteous Allan E Herbison

Circulating estradiol exerts a profound influence on the activity of the gonadotropin-releasing hormone (GnRH) neuronal network controlling fertility. Using genetic strategies enabling neuron-specific deletion of estrogen receptor α (Esr1), we examine here whether estradiol-modulated GABA and glutamate transmission are critical for the functioning of the GnRH neuron network in the female mouse....

2017
Sanjib Chaudhary B. Madhu Krishna Sandip K. Mishra

Forkhead box protein A1 (FOXA1) is essential for the growth and differentiation of breast epithelium, and has a favorable outcome in breast cancer (BC). Elevated FOXA1 expression in BC also facilitates hormone responsiveness in estrogen receptor (ESR)-positive BC. However, the interaction between these two pathways is not fully understood. FOXA1 and GATA binding protein 3 (GATA3) along with ESR...

2013
Yu-Mei Wang Zu-Wang Liu Jing-Bo Guo Xiao-Fang Wang Xin-Xin Zhao Xuan Zheng

BACKGROUND Many published data on the association between single nucleotide polymorphisms (SNPs) in the ESR1 gene and prostate cancer susceptibility are inconclusive. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis is to derive a more precise estimation of this relationship. METHODS A literature search of PubMed, Embase, Web of Science and Chinese Biomedical (CBM) da...

2014
Ebru Kolsal Ayse Serdaroglu Sebnem Soysal

1 Ebru Kolsal1, Ayse Serdaroglu2, Sebnem Soysal2, Esra Gurkas2, Unsal Yılmaz2 1Bakirkoy Dr. Sadi Konuk Research Hospital, Department of Pediatric Neurology, İstanbul, 2Gazi University Faculty of Medicine, Department of Pediatric Neurology, Ankara, Türkiye Oksipital Epilepsilerde Nörokognisyon / Neurocognition in Occipital Epilepsy Cognitive Findings in Benign Childhood Epilepsy with Occipital P...

Journal: :Circulation research 2006
Amanda M Shearman Jackie A Cooper Paul J Kotwinski George J Miller Steve E Humphries Kristin G Ardlie Barbara Jordan Kathryn Irenze Kathryn L Lunetta Stephanie C E Schuit André G Uitterlinden Huibert A P Pols Serkalem Demissie L Adrienne Cupples Michael E Mendelsohn Daniel Levy David E Housman

Understanding the mechanisms by which estrogens affect cardiovascular disease risk, including the role of variation in the gene for estrogen receptor alpha (ESR1), may be key to new treatment strategies. We investigated whether the CC genotype at ESR1 c.454-397T>C is associated with increased risk among men. Study of more than 7000 whites in 5 cohorts from 4 countries provided evidence that gen...

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