The prevalence of GERD increases in asthmatics compared with normal controls. The prevalence of GERD in asthmatics is estimated at between 34% and 89%5,12-16, which probably reflects the variation in GERD definition and populations studied. Although a proportion of patients with GERD have no obvious symptoms, data showed that, among the asthmatics, 77%, 55%, and 24% experienced heartburn, regur...

BACKGROUND Gastroesophageal reflux disease is a risk factor for the development of Barrett's esophagus and esophageal adenocarcinoma. The effect of antireflux therapy on the incidence of esophageal adenocarcinoma is unknown. Acid exposure in vitro induces hyperproliferation via a cyclooxygenase-2 (COX-2) dependent mechanism. Epidemiologic and animal studies suggest that COX inhibitors decrease ...

OBJECTIVE: To verify the association between oxygen desaturation episodes and the dips in pH in infants with chronic obstructive respiratory symptoms. METHOD: Cross-sectional study with children 24 months old or younger hospitalized for investigation of chronic obstructive respiratory symptoms from 1997 to 1999. The patients underwent esophageal pH monitoring associated with transcutaneous oxyg...

Background: The frequency of gastro-esophageal reflux disease is rising, and there has been a real spread of the disease as a consequence of modernity, lifestyle, dietary and behavioral norms, stress, work conditions and life in general. It is usually diagnosed with radiographic methods that employ contrast dyes, endoscopes, catheters and capsules to measure the intra-esophageal pH, impedance m...

Article: Diagnostic utility of impedance-pH monitoring in refractory non-erosive reflux disease CC This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly...

Introduction: Studies have clearly demonstrated an association between infection with human papillomavirus (HPV) and malignant epithelial lesions. This relationship seems to be well established for squamous cell carcinoma of the uterine cervix, for which highand medium-risk HPV types are associated with more than 95% of cases. A literature review correlating esophageal carcinoma with the presen...

Background/Aims Though nocturnal acid-breakthrough (NAB) is common in gastroesophageal reflux disease (GERD) patients, its clinical importance results from esophageal acidification, which has been shown to be uncommon. Ilaprazole, a long-acting proton pump inhibitor, may cause NAB infrequently. Accordingly, we studied prospectively, (1) frequency and degree of esophageal acidification during NA...

Background/Aims Neurologically impaired patients frequently suffer from gastrointestinal tract problems, such as gastroesophageal reflux disease (GERD). In this study, we aimed to define the risk factors for GERD in neurologically impaired children. Methods From May 2006 to March 2014, 101 neurologically impaired children who received 24-hour esophageal pH monitoring at Severance Children's H...