نتایج جستجو برای: esat6

تعداد نتایج: 122  

Journal: :Clinical and vaccine immunology : CVI 2014
Shelley G Rhodes Lucy C McKinna Sabine Steinbach Gilly S Dean Bernardo Villarreal-Ramos Adam O Whelan C Pirson Gareth J Jones Derek Clifford H Martin Vordermeier

We describe here the application of a novel bovine interleukin-2 (IL-2) enzyme-linked immunosorbent assay (ELISA) for the measurement of antigen-specific IL-2 in cattle naturally infected with Mycobacterium bovis and in cattle vaccinated with Mycobacterium bovis BCG and then experimentally challenged with pathogenic M. bovis. Supernatants from whole-blood cultures stimulated with mycobacterial ...

Journal: :Applied and environmental microbiology 2014
Shuxiong Chen Natalie A Parlane Jason Lee D Neil Wedlock Bryce M Buddle Bernd H A Rehm

The tuberculin skin test for diagnosing tuberculosis (TB) in cattle lacks specificity if animals are sensitized to environmental mycobacteria, as some antigens in purified protein derivative (PPD) prepared from Mycobacterium bovis are present in nonpathogenic mycobacteria. Three immunodominant TB antigens, ESAT6, CFP10, and Rv3615c, are present in members of the pathogenic Mycobacterium tubercu...

2013
Nawal Salahuddin Farheen Ali Zahra Hasan Nisar Rao Masooma Aqeel Faisal Mahmood

BACKGROUND Vitamin D enhances host protective immune responses to Mycobacterium tuberculosis by suppressing Interferon-gamma (IFN-g) and reducing disease associated inflammation in the host. The objectives of this study were to determine whether vitamin D supplementation to patients with tuberculosis (TB) could influence recovery. METHODS Two hundred and fifty nine patients with pulmonary TB ...

2014
Xiaoyan Feng Xiqin Yang Bingshui Xiu Shuang Qie Zhenhua Dai Kun Chen Ping Zhao Li Zhang Russell A Nicholson Guohua Wang Xiaoguo Song Heqiu Zhang

BACKGROUND The present study was aimed to evaluate whether IgG, IgM and IgA antibodies levels detected against a novel Mycobacterium tuberculosis polyprotein 38 F-64 F (with 38 F being the abbreviation for 38kD-ESAT6-CFP10 and 64 F for Mtb8.4-MPT64-TB16.3-Mtb8) are suitable for diagnosing active tuberculosis, and for monitoring the efficacy of chemotherapy on TB patients. METHODS In this stud...

2008
Ayman Saleem

Despite the discovery of the causative agent of tuberculosis (TB), Mycobacterium tuberculosis, more than 120 years ago TB remains a major worldwide health problem. Currently, the attenuated strain of M. bovis, Bacille Calmette-Güerin (BCG) is the only vaccine available against TB. Although BCG is the world's most widely used vaccine, its protective value as an anti-TB vaccine for adults in cert...

2018
G Ameni K Tafess A Zewde T Eguale M Tilahun T Hailu A Sirak F J Salguero S Berg A Aseffa R G Hewinson H M Vordermeier

Bovine tuberculosis (bTB) is highly prevalent in intensive dairy farms of the urban "milk-sheds" in Ethiopia, and vaccination could be a cost-effective disease control strategy. In the present study, the efficacy of Bacillus Calmette-Guerin (BCG) to protect against bTB was assessed in Holstein-Friesian calves in a natural transmission setting. Twenty-three 2-week-old calves were subcutaneously ...

Journal: :PLoS ONE 2008
Farba Karam Fatou Mbow Helen Fletcher Cheikh S. Senghor Koura D. Coulibaly Andrea M. LeFevre Ndeye F. Ngom Gueye Tandakha Dieye Papa S. Sow Souleymane Mboup Christian Lienhardt

BACKGROUND Detection and treatment of latent TB infection (LTBI) in HIV infected individuals is strongly recommended to decrease morbidity and mortality in countries with high levels of HIV. OBJECTIVE To assess the validity of a newly developed in-house ELISPOT interferon-gamma release assay (IGRA) for the detection of LTBI amongst HIV infected individuals, in comparison with the Tuberculin S...

2014
Paulin N. Essone Novel N. Chegou Andre G. Loxton Kim Stanley Magdalena Kriel Gian van der Spuy Kees L. Franken Tom H. Ottenhoff Gerhard Walzl

BACKGROUND We previously identified Mycobacterium tuberculosis (M.tb) antigen-induced host markers that showed promise as TB diagnostic candidates in 7-day whole blood culture supernatants. The aim of the present study was to evaluate the utility of these markers further, and cross-compare results with short-term antigen stimulated and unstimulated culture supernatants. METHODS We recruited 1...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید