OBJECTIVE Alexithymia and depressive mood have been described as important dimensions of several medical diseases. Systemic lupus erythematosus is a chronic condition characterized by unpredictable clinical manifestations. The relationships between alexithymia, depression, and illness perception were examined in systemic lupus erythematosus patients. The interrelationships between psychological...

1. Martín JM, Ramón D, Monteagudo C, Llombart B, Castelló A, Molina I, et al. Lupus eritematoso cutáneo subagudo inducido por fármacos. Actas Dermosifiliogr. 2004;95:117--9. 2. Callen JP. Drug-induced subacute cutaneous lupus erythematosus. Lupus. 2010;19:1107--11. 3. Marzano AV, Vezzoli P, Crosti C. Drug-induced lupus: an update on its dermatologic aspects. Lupus. 2009;18:935--40. 4. Callen JP...

BACKGROUND The gene deletion responsible for the type I human complement C2 deficiency was reported in 1992. The purpose of our study is to evaluate clinical and immunological characteristics of 11 patients with lupus erythematosus and type I C2 deficiency. OBSERVATIONS We observed 5 patients with a homozygous C2 deficiency and 6 with a heterozygous C2 deficiency. Eight patients had systemic ...

  Thymoma is a term that should be restricted to neoplasms of thymic epithelial cells, irrespective of the presence or the number of lymphocytes. The usual location of thymoma is the antrosuperior mediastinum; however, this tumor can also occur in other mediastinal compartments, in the neck, within the thyroid gland, in the pericardial cavity, the pulmonary hilum, within the lung parenchyma, o...

Immune response to ultraviolet radiation-modified skin antigens has been suggested as a pathomechanism of skin lesions in discoid lupus erythematosus and polymorphous light eruption. In order to elucidate the role of T-lymphocyte subsets in this response, we studied the distribution of CD45RO+, CD45RA+ and CD31+ cells and the endothelial expression of adhesion molecules E-selectin/P-selectin, i...

Patients with systemic lupus erythematosus have a poor prognosis of pregnancy, since it is associated with significant maternal and fetal morbidity, including spontaneous miscarriage, pre-eclampsia, intrauterine growth restriction, fetal death and pre-term delivery. We report a case with successful pregnancy in a patient with systemic lupus erythematosus and hypertension. A 39-year-old nullipar...

The first description of lupus erythematosus was given by Pierre Louis Alphée Cazenave, who was a coworker of Laurent-Théodore Biett, in 1851. He used the French term “lupus erythemateux.” In 1856 Ferdinand Hebra translated this work into German and coined the term lupus erythematosus, which is the Latin translation, and in 1863 Isidor Neumann propagated the Greek term “lupus erythematodes.” In...

Systemic lupus erythematosus is an autoimmune disorder affecting multiple organ systems. Patients with systemic lupus erythematosus exhibit a bimodal pattern of mortality, with those who have had the disease for 5 to 10 years being at increased risk of cardiovascular disease, particularly myocardial infarction. Elevated levels of conventional cardiovascular risk factors promote vascular damage ...

Bullous systemic lupus erythematosus is one of the rare autoantibody mediated skin manifestation of systemic lupus erythematosus (SLE) demonstrating subepidermal blistering with neutrophilic infiltrate histologically. We present a case of a 40-year-old Hispanic female who presented with a several months' history of multiple blistering pruritic skin lesions involving the face and trunk, a photos...

Lupus erythematosus is an autoimmune disease that affects primarily women and whose cause is unknown. The diagnosis arises from a patient that may show singular signs or signs of a multisystem disease; there is a presence of autoantibodies, and other diseases with similar properties are ruled out. Two main forms of the disease exist; the discoid and the disseminated forms. Hippocrates was the f...