Gene fusions involving ETS family transcription factors (mainly TMPRSS2-ERG and TMPRSS2-ETV1 fusions) have been found in ~50% of human prostate cancer cases. Although expression of TMPRSS2-ERG or TMPRSS2-ETV1 fusion alone is insufficient to initiate prostate tumorigenesis, they appear to sensitize prostate epithelial cells for cooperation with additional oncogenic mutations to drive frank prost...

ERG (Ets-related gene) is an ETS transcription factor that has recently been shown to regulate a number of endothelial cell (EC)-restricted genes including VE-cadherin, von Willebrand factor, endoglin, and intercellular adhesion molecule-2. Our preliminary data demonstrate that unlike other ETS factors, ERG exhibits a highly EC-restricted pattern of expression in cultured primary cells and seve...

The fusion between ERG coding sequences and the TMPRSS2 promoter is the most prevalent in prostate cancer (CaP). The presence of two main types of TMPRSS2-ERG fusion transcripts in CaP specimens, Type I and Type II, prompted us to hypothesize that the cumulative actions of different ERG variants may impact CaP development/progression. Using TMPRSS2-ERG3 (Type I) and TMPRSS2-ERG8 (Type II) expre...

PURPOSE Upregulation of nuclear C-MYC protein has been reported to be an early event in prostate cancer (PCa); however, its clinicopathological and prognostic significance remain controversial. We determined the association of nuclear C-MYC protein expression with clinicopathological parameters, prognosis, ETS-related gene (ERG) expression, and TMPRSS2-ERG status in PCa. METHODS Nuclear C-MYC...

suicide is a major public health concern, with approximately one million people committing suicide world-wide each year .risk factors for suicidal behavior include, psychiatric and medical illness, impulsivity, aggression, alcohol and drug abuse specially stimulants, and  stress. neurobiological, brain mappings and biochemical studies have revealed that suicide victims experiencing a large numb...

OBJECTIVE To investigate whether messenger ribonucleic acid (mRNA) expression of TMPRSS2-ERG fusion gene, a suggested prostate cancer (PCa) biomarker, was specific to cancerous lesions alone and to study the expression of SPINK1 and PCA3 mRNAs in the same cohort to also explore the proposed mutual exclusivity of TMPRSS2-ERG and SPINK1 expression. METHODS Levels of 2 TMPRSS2-ERG transcripts, P...

Earlier research on phenotype/genotype relationships in color vision has shown imperfect predictability of color matching from the photopigment spectral sensitivities inferred from molecular genetic analysis. We previously observed that not all of the genes of the X-chromosome linked photopigment gene locus are expressed in the retina. Since sequence analysis of DNA does not necessarily reveal ...

background: apoptosis is a process that plays an important role during early stage of implantation. the aim of this study was to investigate the incidence of apoptosis in mice endometrium after ovarian stimulation at implantation period. methods: nmri female mice were divided into two groups: 1) control group, which were rendered pseudopregnant by vaginal stimulation and 2) experimental group, ...

schizophrenia (scz) is a complex disorder with no clarified etiology or biological diagnosis.  symptoms of schizophrenia including positive, negative and cognitive deficits.the neurodegenrative and neurodevelopmental hypothesis are main views  about the pathophysiology of schizophrenia. neuregulin 1 is one of four proteins in the neuregulin family that act on the egfr family of receptors. nrg1 ...