Halogenation of organic compounds plays diverse roles in biochemistry, including selective chemical modification of proteins and improved oral absorption/blood-brain barrier permeability of drug candidates. Moreover, halogenation of aromatic molecules greatly affects aromatic interaction-mediated self-assembly processes, including amyloid fibril formation. Perturbation of the aromatic interacti...

The inhibition of ErbB2 by the use of human antibodies can be a valuable strategy for the treatment of breast and gastric cancer. Trastuzumab, a humanized anti-ErbB2 antibody in clinical use, is effective but can engender resistance as well as cardiotoxicity. ImmunoRNases, made up of a human anti-ErbB2 scFv and human pancreatic ribonucleases (HP-RNases), have been engineered to overcome the lim...

Post-menopausal women experience variable biological and psychological changes. The effect of reduced levels of estrogen can effect on post-menopausal depression. Estrogen triggers physiological responses by binding to the estrogen receptor (ER). Two subtypes of ER, ERa and ERb are now known. We investigated the significance of ERa and ERb polymorphisms and post-menopasal depression in this stu...

Protein kinases were separated from rat kidney nuclear extract by hydroxylapatite column chromatography. Five (I-V) different protein kinases were isolated when histone was used as a substrate. Two (I and III) of them stimulated phosphorylation of c-erb A-beta protein (50 kDa) expressed in Escherichia coli. The c-erb A product has an activity of high affinity T3 binding. One (I) of the kinases ...

This paper describes the simulation of the earth radiation budget (ERB) as viewed by Triana and the development of correction models for converting Trianaviewed radiances into a complete ERB. A full range of Triana views and global radiation fields are simulated using a combination of datasets from ERBE (Earth Radiation Budget Experiment) and ISCCP (International Satellite Cloud Climatology Pro...

ISSN: 1742-9145 (Print) 1742-9153 (Online) Journal homepage: http://www.tandfonline.com/loi/tjpi20 Induction of root-resistance by leaf-herbivory follows a vertical gradient Matthias Erb , Christelle A.M. Robert & Ted C.J. Turlings To cite this article: Matthias Erb , Christelle A.M. Robert & Ted C.J. Turlings (2011) Induction of root-resistance by leaf-herbivory follows a vertical gradient, Jo...

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A central mechanism for controlling circadian gene amplitude remains elusive. We present evidence for a "facilitated repression (FR)" model that functions as an amplitude rheostat for circadian gene oscillation. We demonstrate that ROR and/or BMAL1 promote global chromatin decondensation during the activation phase of the circadian cycle to actively facilitate REV-ERB loading for repression of ...

We have studied the two estrogen receptor (ER) subtypes, ERa and ERb, and chimeric constructs with ERa and ERb to examine the bioactivities of these receptors and their responses to estrogen and antiestrogen ligands. Transcriptional activity of ERb is highly dependent on cell/promoter context and on the nature of the ligand. ERb activated significant levels of transcription in response to estro...

The outbreak of COVID-19 has significantly increased the number climbers who enter reserve areas and use mountain houses compared with same period in 2019. Mountaineering become a popular activity causing forest managers to pay more attention tourist environmentally responsible behavior (ERB) which is key maintain land sustainable management. Therefore, purpose this study explore influence clim...