A 5 year old boy developed liver failure secondary to infection with Epstein-Barr virus. He was subsequently shown to have a partial C4 complement deficiency. The importance of considering Epstein-Barr virus as a cause of fulminant hepatic failure and the need to assess immune state in such an event is emphasised.

We prove that there is a correspondence between Ramanujan-type formulas for 1/π and formulas for Dirichlet L-values. Our method also allows us to reduce certain values of the Epstein zeta function to rapidly converging hypergeometric functions. The Epstein zeta functions were previously studied by Glasser and Zucker.

AFFILIATIONS: EPSTEIN—Center for Health and the Global Environment, Harvard Medical School, Boston, Massachusetts; MCCARTHY—Museum of Comparative Zoology, Harvard University, Cambridge, Massachusetts CORRESPONDING AUTHOR ADDRESS: Paul R. Epstein, Center for Health and the Global Environment, Harvard Medical School, Landmark Center, 401 Park Dr., Boston, MA 02215 E-mail: [email protected]...

Pure human gamma-interferon as well as alpha-interferon inhibited induction of immunoglobulin synthesis by Epstein-Barr virus but not by pokeweed mitogen in B lymphocytes from adult but not from newborn humans. The interferons inhibited the infected B lymphocytes directly, irrespective of the Epstein-Barr virus immune status of the donor, and their inhibitory effect was synergistic.

In this paper we develop a method to compute the Burns-Epstein invariant of a spherical CR homology sphere, up to an integer, from its holonomy representation. As application, we give a formula for the Burns-Epstein invariant, modulo an integer, of a spherical CR structure on a Seifert fibered homology sphere in terms of its holonomy representation.

A transfection assay with a lymphoblastoid cell line infected with Epstein-Barr virus was used to compare the abilities of type 1 and type 2 EBNA2 to sustain cell proliferation. The reduced proliferation in cells expressing type 2 EBNA2 correlated with loss of expression of some cell genes that are known to be targets of type 1 EBNA2. Microarray analysis of EBNA2 target genes identified a small...

The Enzygnost anti-Epstein-Barr virus enzyme-linked immunosorbent assay (ELISA) system, which is based on a defined antigen mixture and on detection of antibodies of the immunoglobulin G (IgG), IgM, and IgA classes, was evaluated for its reliability in diagnosing Epstein-Barr virus infections in childhood. With samples from 66 children, the Epstein-Barr virus status and the infection phase were...

High-molecular-weight DNA from cell line Raji (derived from Burkitt's lymphoma), which contains 50-60 copies of Epstein-Barr virus DNA per cell, was fractionated in neutral solution by several cycles of CsCl gradient centrifugation in fixed-angle rotors. Under the fractionation conditions used, intact Epstein-Barr virus DNA from virus particles can be separated from the less-dense cellular DNA....

Purified recombinant protein encoded by the BXLF-I open reading frame of the Epstein-Barr virus genome has thymidine kinase activity. The substrate behaviors of various nucleosides toward this enzyme were tested. Halogenated deoxyuridines, zidovudine, and bromovinyldeoxyuridine are efficient substrates, while acyclovir and dihydroxypropylmethylguanine are relatively poor substrates for the Epst...

In this paper we develop a method to compute the Burns-Epstein invariant of a spherical CR homology sphere, up to an integer, from its holonomy representation. As an application, we give a formula for the Burns-Epstein invariant, modulo an integer, of a spherical CR structure on a Seifert fibered homology sphere in terms of its holonomy representation.