background: endometriosis is a complex estrogen-dependent disease that is defined as the presence of endometrial gland and stroma outside the uterine cavity. although the exact mechanism for the development of endometriosis remains unclear, there is a large body of research data and circumstantial evidence that suggests a crucial role of estrogen in the establishment and maintenance of this dis...

We report the generation of a 6 pC, 23 MeV electron bunch with the energy spread ± 3.5% by using 2 TW, 80 fs high contrast laser pulses interacting with helium gas targets. Within the optimized experimental condition, we obtained quasi-monoenergetic electron beam with an ultra-small normalized divergence angle of 92 mrad, which is at least 5 times smaller than the previous LPA-produced bunches....

The ability to de novo synthesize purines has been associated with the intracellular survival of multiple bacterial pathogens. Uropathogenic Escherichia coli (UPEC), the predominant cause of urinary tract infections, undergoes a transient intracellular lifestyle during which bacteria clonally expand into multicellular bacterial communities within the cytoplasm of bladder epithelial cells. Here,...

TAFII70, a member of the basal transcription complex implicated in p53-mediated transcription, is synthesized as several alternately spliced variants. The predominant forms found in normal and neoplastic breast epithelial cells are shown to be 72 kDa (TAFII70) and 78 kDa (TAFII80). Most cancers express higher levels of the TAFII80 isoform, whereas normal breast epithelia express higher levels o...

Pap test is already part of the successful examinations in early detection cervical cancer. The objective this 1-year retrospective study (2019-2020), to assess importance periodic tests, distribution squamous and glandular anomalies, as well determining predominant categories for each anomaly, 4123 cases Hygeia hospital, Albania. age group 60- 69 years was with most anomalies. 72.8% women incl...

Introduction. Sarcomas refer to a group of heterogeneous non-epithelial malignant tumors originating from connective tissue. These are characterized by extremely aggressive local growth, relatively low incidence lymphogenic metastases, predominant and early hematogenic generalization. most oft en metastasize the lungs. Materials methods. The paper describes case successful surgical treatment fo...

Increasing evidence indicates that Liver X Receptors (LXRs) have some anticancer properties. We recently demonstrated that LXR ligands induce colon cancer cell pyroptosis through an LXRβ-dependent pathway. In the present study, we showed that human colon cancer cell lines presented differential cytoplasmic localizations of LXRβ. This localization correlated with caspase-1 activation and cell de...

Submit Manuscript | http://medcraveonline.com Hakansson and Molin [4] suggests that microbial colonization of the GI tract affects the composition of GALT. Once the intestine is exposed to microorganisms, intraepithelial lymphocytes increase; germinal centers with immunoglobulin-producing cells arise rapidly in follicles and in the lamina propria and serum immunoglobulin concentrations increase...

Several studies have been performed to understand the influence of titanium dioxide nanoparticles (TiO2-NPs) on cell function; however the effects of nanoparticle exposure on the plasma membrane have not been addressed so far. Since this interaction may alter cell metabolism and integrity, it is of importance to understand the modifications of the cell membrane, in particular of epithelial cell...