Introduction To evaluate the expression patterns of cytokeratin (K) 12, 13, and 19 in normal epithelium of the human ocular surface to determine whether K13 could be used as a marker for conjunctival epithelium. Methods: Total RNA was isolated from the human conjunctiva and central cornea. Those transcripts that had threefolds or higher expression levels in the conjunctiva than the cornea wer...

Objective(s): Growing evidences have indicated microRNAs as modulators of tumor development and aggression. On the other hand, a phenomenon known as epithelial-mesenchymal transition (EMT) that indicates a transient phase from epithelial-like features to mesenchymal phenotype is a key player in tumor progression.  In this study, we aimed to assess the potential impacts...

Apocrine cystomatosis, also called epitrichial sweat gland is a non-neoplastic condition characterised by multiple dilated cysts of origin. Histopathologically, these comprise two layers cells: an inner layer glandular epithelial cells and outer myoepithelial cells. A case apocrine cystomatosis was admitted to local hospital. The microscopic investigation revealed that some enlarged show...

slug (snai2), a regulator of epithelial-to-mesenchymal transition (emt), is a zinc finger transcription factor involved in neurulation. intriguingly, snai2 gene expression has been linked to the aggressiveness of neuroblastoma, melanoma and lung, colon, ovarian and breast carcinoma. of note, many metastatic cancers recapitulate emt to enhance cell motility and invasion. moreover, metastasis is ...

Glomerular development of the kidney was studied in newborn rats by electron microscopy. Four different stages of glomerular development were defined: vesicle fonnation, S-shaped body stage, capillary loop fonnation, and glomerular maturation. In the fust stage, the mesenchymal cells form a spheroid mass. This is followed by the S-shaped body stage in which clefts appear in the mass. Afte...

Two set of 2-aryl-5,6-dihydropyrrolo[2,1-a] isoquinolines were designed and synthesized to evaluate their biological activities as topoisomerase inhibitors. Cytotoxic activity of the synthesized compounds 4a-e and 7a-d was assessed against several human cancer cell lines, including MCF-7 (breast cancer cell), HepG2 (liver hepatocellular cells), A549 (adenocarcinomic human alveolar basal epithel...

In this study, we examined the effect of a combination surface topographies (fiber alignments) and different stiffness poly(L-lactic acid) (PLLA) substrates on direct relationship between anti-cancer drug (CDDP) sensitivity for MDA-MB-231 cells mesenchymal properties under both normal hypoxic conditions. addition, studied induction epithelial–mesenchymal transition (EMT). The CDDP treatment hyp...

background and objective: smoking can be associated with the decreasing gingival blood flow and epithelial changes. the aim of this study was to evaluate the histopathological changes of gingival epithelium and connective tissue in smokers. methods: the study was case-control. sixty male patients (28 smokers and 32 nonsmokers) suffering chronic periodontitis were participated in the study. peri...