Objective(s): Hyperuricemia is a risk for cardiovascular and metabolic diseases, but the mechanism is ambiguous. Increased intestinal permeability is correlated with metabolic syndrome risk factors. Intestinal epithelial cells play a pivotal role in maintaining intestinal permeability. Uric acid is directly eliminated into intestinal lumen, however, the mechanism and e...

In a systematic effort to identify a potent antiproliferative agent, four complexes of vanadium containing maltol and deferiprone ligands were synthesized and evaluated for their cytotoxic activity against five human and animal cancer cell lines, including human breast cancer cells (MCF-7), human cervix epithelial carcinoma (HeLa), human colon cancer cell line (HT-29), human leukemia cell line ...

Background and objective:Cytogenetic damage in exfoliated buccal epithelial cells due to environmental and occupational exposure is often monitored by micronucleus (MN) assay using liquid based cytology (LBC) preparations. This study was performed to evaluate MN in exfoliated buccal epithelial cells of building construction workers using LBC preparations. <strong...

  Background :Cell proliferation is one of the most critical factors in metastasis and prognosis of the malignant tumors.Recent investigations show that the eosinophil granolosytes have an important role in developing of malignant tumors. The relation between cell proliferation and eosinophilic infiltration in oral squamous cell carcinoma (OSCS) with prognosis is unclear.The aim of this study w...

Cell contractility is mainly imagined as a force dipole-like interaction based on actin stress fibers that pull cellular adhesion sites. Here, we present different type of isotropic contractions within the actomyosin cortex. Measuring mechanosensitive cortical suspended cells among various cell lines allowed us to exclude effects caused by fibers. We found epithelial display higher tension than...

Changes in cell-cell and cell-substrate adhesion markers are increasingly used to characterize disease onset progression. However, these relationships depend on both the biochemical molecular association between cells their extracellular matrix, as well biophysical mechanical properties orchestrated by cytoskeletal, membrane matrix components. To fully appreciate role of cell when determining n...

Abstract To understand the potential effects of cancer cells on surrounding normal mammary epithelial cells, we performed direct co-culture non-tumorigenic MCF10A and various breast cells. Firstly, observed dynamic cell–cell interactions between including lamellipodia or nanotube-like contacts transfer extracellular vesicles. Co-cultured exhibited features epithelial-mesenchymal transition, sho...

background :cell proliferation is one of the most critical factors in metastasis and prognosis of the malignant tumors.recent investigations show that the eosinophil granolosytes have an important role in developing of malignant tumors. the relation between cell proliferation and eosinophilic infiltration in oral squamous cell carcinoma (oscs) with prognosis is unclear.the aim of this study was...