PURPOSE Epilepsy surgery is associated with a risk of cognitive deterioration, but improvement has also been reported. Improvements have mostly been attributed to seizure control, neglecting changes in drug treatment during the observation period. We evaluated whether changes of antiepileptic treatment affect cognitive outcome one year after epilepsy surgery. METHODS This retrospective study ...

Epilepsy is the third most common chronic brain disorder which is characterized by an enduring predisposition to generate seizures. Mesial Temporal Lobe Epilepsy (MTLE) is the most common type of refractory epilepsy. Increasing evidence indicates that neuroinflammation plays a critical role in the pathogenesis of MTLE. Hundreds of micro-RNAs have been found to be abnormally expressed in epilept...

It is not known whether conservative or early aggressive (resective surgery with or without radiotherapy) management is better for tumours presenting with epilepsy. The prognosis of 560 patients with a clinical and CT diagnosis of intrinsic supratentorial tumour was examined retrospectively. Epilepsy was the first symptom in 164 patients. Histological confirmation of diagnosis was available in ...

Despite many epilepsy patients respond to antiepileptic drugs (AED) successfully, more than 30% of patients continue to have seizures on multiple AEDs. The refractory epilepsy increases the risk of cognitive deterioration, psychosocial dysfunction, and sudden unexpected death of epilepsy patients (SUDEP). It is important to identify refractory epilepsy early and make the goal of epilepsy treatm...

OBJECTIVE To calculate the chance of a seizure in the next year (COSY) for seizures with impaired awareness in those experiencing auras only, those with no seizures and those with continuing seizures. Epilepsy surgery is an effective treatment for refractory focal epilepsy. Driving is an important factor affecting quality of life. In the UK, driving is not permitted if focal seizures with no im...

PURPOSE Most epilepsy surgery candidates are young adults. Outcome reports after epilepsy surgery in patients ≥50 years are few and varying. The aim of this study was to describe patient characteristics of older compared to younger adults and analyse seizure, complication and vocational outcomes in a large population-based series. METHODS We analysed data from the Swedish National Epilepsy Su...

Epilepsy is one of the most common neurologic diseases around the world and more significantly in Iran (0.4-1 % worldwide and 5% in Iran). Almost one-third of these patients suffer from treatment-resistant epilepsy, which reduces their quality of life by recurring epileptic onsets. There are different approaches for the treatment of both treatment-resistant and treatment-nonresistant epilepsy, ...

Introduction The average time between epilepsy onset and surgery is currently approximately 20 years. In epilepsy, research on the problem of late referral for neurosurgical treatment crucial. We aimed to investigate gender differences in willingness patients undergo focal drug-resistant (DRE). Methods. It was a single-centre retrospective, observational, longitudinal cohort study outpatient fu...

Even though epilepsy is one of the most prevalent and debilitating neurological disorders, our knowledge its precise pathogenesis therapeutic rationale limited. Sixty-five million individuals throughout globe are living with epilepsy, which imposes a substantial burden in terms disability, mortality, comorbidities, stigma, expenses due to seizures. Significant progress has been made last decade...

Seizure freedom after resective epilepsy surgery is not obtained in a substantial number of patients with medically intractable epilepsy. Functional neural network analysis is a promising technique for more accurate identification of the target areas for epilepsy surgery, but a better understanding of the correlations between changes in functional network organization due to surgery and postope...