The large specific granule of the human eosinophil contains a number of low molecular weight, highly basic proteins that have been purified to homogeneity, including the major basic protein (MBP) (1-3), 1 the eosinophil cationic protein (4, 5), and the eosinophil-derived neurotoxin (6, 7). The comparative physicochemical and immunochemical characteristics of these proteins have been examined in...

The large specific granule of the human eosinophil contains a number of low molecular weight, highly basic proteins that have been purified to homogeneity, including the major basic protein (MBP) (1-3), 1 the eosinophil cationic protein (4, 5), and the eosinophil-derived neurotoxin (6, 7). The comparative physicochemical and immunochemical characteristics of these proteins have been examined in...

Adherence of eosinophils to vascular endothelium and their accumulation at sites of allergen challenge are hallmarks of allergic inflammation. However, the molecular mechanisms mediating eosinophil adhesion under conditions of blood flow are not well understood. The present studies were performed to identify the receptors on human eosinophils involved in initiating adhesion to activated endothe...

Although an association between high blood eosinophil counts and endomyocardial disease has been known for nearly a hundred years, the reasons for this were not understood. Brockington, Luzzatto and Osunkoya (1970) suggested that eosinophil leucocytes, in susceptible persons, by some unknown mechanisms, cause endomyocardial damage. Evidence to support this possibility has come from three source...

Extracellular acidification has been observed in allergic inflammatory diseases. Recently, we demonstrated that the proton-sensing receptor G protein-coupled receptor 65 (GPR65) regulates eosinophil survival in an acidic environment in vitro and eosinophil accumulation in an allergic lung inflammation model. For mast cells, another inflammatory cell type critical for allergic responses, it rema...

herein, we reported on a middle-aged woman presented with painless cervical lymphadenopathy. past medical history was not significant. pathologic examination of incisional biopsy show partial effacement of lymph node architecture with many reactive inflammatory cells admixed with reed-sternberg cells, many charcot-leyden crystals, and noncaseating granuloma. immunohistochemical staining was pos...

Monocyte chemotactic protein-4 (MCP-4) is a newly identified C-C chemokine with potent eosinophil chemoattractant properties. We describe studies of its biological activity in vitro to induce chemotaxis of peripheral blood eosinophils and to induce histamine release from IL-3-primed peripheral blood basophils. MCP-4 and eotaxin caused a similar rise in eosinophil intracytoplasmic Ca2+ and compl...

Herein, we reported on a middle-aged woman presented with painless cervical lymphadenopathy. Past medical history was not significant. Pathologic examination of incisional biopsy show partial effacement of lymph node architecture with many reactive inflammatory cells admixed with Reed-Sternberg cells, many Charcot-Leyden crystals, and noncaseating granuloma. Immunohistochemical staining was pos...

Biopsy specimens and tissues obtained at necropsy from two women who died after developing the Churg-Strauss syndrome were analysed to see whether granulomas in these patients contained activated eosinophils or secreted eosinophil cationic proteins, or both. Immunocytochemical studies with monoclonal antibody EG2 showed large amounts of eosinophil cationic protein and eosinophil protein-X (whic...