This article reviews our contribution in the ®eld of the cobalt(I)-mediated cyclizations. The use of new unsaturated partners such as allenes extend the scope and the utility of the previously developed intramolecular [2‡2‡2] cyclotrimerization. The presence of chiral auxiliaries induced high level of diastereoselectivity in the enediynes cyclization. The discovery of cobalt(I) catalyzed ene-ty...

The title compound, C19H22N2O3, {systematic name (1aR,4E,7aS,8E,10aS,10bR)-1a,5-dimethyl-8-[(pyrimidin-5-yl)-methylid-ene]-2,3,6,7,7a,8,10a,10b-octa-hydro-oxireno[2',3':9,10]cyclo-deca-[1,2-b]furan-9(1aH)-one} was obtained from the reaction of parthenolide [systematic name (1aR,7aS,10aS,10bR,E)-1a,5-dimethyl-8-methyl-ene-2,3,6,7,7a,8,10a,10b-octa-hydro-oxireno[2',3':9,10]cyclodeca-[1,2-b]furan-...

Substitution of a H atom by an alkyl group on the terminal carbon of the alkyne moiety of 1,6-fullerenynes has a strong impact on the products of the reaction undergone by this species after thermal treatment. While the reaction of 1,6-fullerenynes bearing an unsubstituted alkyne moiety results in the cycloaddition of the alkyne group to the fullerene double bond leading to cyclobutene-fused de...

Novel thiophenophan-1-enes, which are composed of a dithienylethene unit and a chiral bridge, were synthesized and obtained as optically-active single diastereomers. Upon UV irradiation, the open-form isomers afforded single diastereomers of the closed form in 100% diastereo-excess, indicating that this system undergoes a fully diastereospecific photochromic reaction.

Thiol-ene and thiol-yne photomediated conjugations have received substantial attention in research practice. Herein is presented the photodisulfidation of alkenes based on radical-mediated 1:1 reaction a disulfide vinyl ether, which provides an additional route for formation types sulfides seen thiol-ene polymers. Although similar linkages are formed, this approach starting with disulfides expe...

OBJECTIVE To provide further evidence for the ethnomedicinal use of the Eastern Nigeria mistletoe, Loranthus micranthus (L. micranthus), as an immunostimulant. METHODS Solvent fractions from the crude extract of the mistletoe plant was obtained and screened by the cell mediated delayed type hypersensitivity reaction (DTHR) model in mice. Then the immunomodulatory potentials of a major lupane ...

The ene-reductases mediated bioreduction of a selection of open-chain α-alkyl-β-aryl enones afforded the corresponding saturated α-chiral ketones in high yield and optical purity in several cases. The stereo-electronic requirements of the reaction have been investigated, considering the nature and location of substituents on the aromatic ring as well as the steric hindrance at the α-position an...

The flavoprotein 2-aminobenzoyl-CoA monooxygenase/reductase from the eubacterium Azoarcus evansii catalyzes the dearomatization of 2-aminobenzoyl-CoA. The reaction consists in an O2-dependent monooxygenation at the benzene position 5, which is followed immediately by an NADH-dependent hydrogenation of the intermediate at the same catalytic locus. The reaction was studied by 1H, 2H, and 13C NMR ...