Sorbitol accumulation is postulated to play a role in skeletal muscle dysfunction associated with diabetes. The purpose of this study was to determine the effects of insulin and of endurance exercise on skeletal muscle sorbitol levels in streptozotocin-induced diabetic rats. Rats were assigned to one experimental group (control sedentary, control exercise, diabetic sedentary, diabetic exercise,...

BACKGROUND Until now, no experimental study has directly assessed the arrhythmogenesis of chronic consumption of anabolic androgenic steroids along with moderate-intensity endurance exercise. OBJECTIVES We evaluated the influence of integration of anabolic androgenic steroids along with moderate-intensity endurance exercise on susceptibility to lethal ventricular arrhythmias in rat. MATERIA...

INTRODUCTION Pentraxin 3 (PTX3), which is mainly produced by endothelial cells, macrophages, and smooth muscle cells in the atherosclerotic region, has a cardioprotective effect. Endurance exercise training has also been known to offer cardioprotection. However, the effect of regular endurance exercise on PTX3 is unknown. This study aimed to investigate whether plasma PTX3 concentrations increa...

Ischemia-reperfusion-induced calcium overload and production of reactive oxygen species can trigger apoptosis by promoting the release of proapoptotic factors via the mitochondrial permeability transition pore. While it is clear that endurance exercise provides cardioprotection against ischemia-reperfusion-induced injury, it is unknown if exercise training directly alters mitochondria phenotype...

INTRODUCTION Exercise reduces arterial and central venous blood pressures during recovery, which contributes to its valuable anti-hypertensive effects and to facilitating hypervolemia. Repeated sprint exercise potently improves metabolic function, but its cardiovascular effects (esp. hematological) are less well-characterized, as are effects of exercising upper versus lower limbs. The purposes ...

Wenz T, Diaz F, Hernandez D, Moraes CT. Endurance exercise is protective for mice with mitochondrial myopathy. J Appl Physiol 106: 1712–1719, 2009. First published March 12, 2009; doi:10.1152/japplphysiol.91571.2008.—Defects in the mitochondrial ATP-generating system are one of the most commonly inherited neurological disorders, but they remain without treatment. We have recently shown that mod...

Endurance exercise training elicits physiological adaptations within the body. One of the adaptations observed with endurance training is the body's ability to oxidize increased amounts of fat as energy during exercise. A critical role in this energy substrate shift is mediated by the mitochondria. The mechanisms for adaptation at the mitochondria and their relative importance to the energy sub...

conclusions the trunk stabilization exercises are more effective than conventional back care exercises in the rehabilitation of patients with chronic lbp. results the results of the study demonstrated significant improvements in abdominal muscle endurance and reduction in vas and modq score of both groups (p = 0.001). the trunk stabilization exercise group showed greater gains in abdominal musc...