OBJECTIVE The aims of this study were to study further the previously observed 2-fold higher prevalence of endstage renal disease (ESRD) due to diabetic nephropathy (DN) in African-American (AA) women, when compared to AA men, and to identify factors predictive of renal survival in this population. DESIGN Cross-sectional analysis of DN in an academic renal clinic. METHODS We identified and ...

Juvenile nephronophtisis (NPHP), a rare recessive cystic kidney disease, represents the most common genetic cause of endstage renal disease in the first two decades of life. A few studies have investigated the clinical and molecular characteristics of NPHP and related ciliopathies in the Tunisian population. We reported the results of the largest molecular genetic investigation. Since 2004, 71 ...

Current epidemiological data from the USA, Europe, Asia and the Indian subcontinent, Africa, the Far East, South America, the Middle East and Eastern Europe all point to the increasing incidence of renal failure encompassing acute kidney injury (AKI), chronic kidney disease (CKD) and endstage renal disease (ESRD). While the explanations for these worldwide epidemics remain speculative, it must ...

Diabetic nephropathy (DN) is the leading cause of endstage renal disease (ESRD) in developed countries. Several environmental and genetic factors predict the development and progression of DN. The renin-angiotensin system was demonstrated to be involved in the development of DN. We evaluated the association between rs4340 of the angiotensin-converting enzyme (ACE) gene and DN in Caucasians with...

Mogensen1 made the unique observation that lowering blood pressure in patients with type 1 diabetes and diabetic nephropathy reduced the rate of loss in kidney function. In that study of five insulin-dependent proteinuric men with long-standing diabetes, blood pressure was lowered with combinations of furosemide, prazosin, hydralazine, and -blockers. This observation presaged what has become a ...

Current epidemiological data from the USA, Europe, Asia and the Indian subcontinent, Africa, the Far East, South America, the Middle East and Eastern Europe all point to the increasing incidence of renal failure encompassing acute kidney injury (AKI), chronic kidney disease (CKD) and endstage renal disease (ESRD). While the explanations for these worldwide epidemics remain speculative, it must ...

BACKGROUND Using flame photometry technique in the 1970s, the normal value of anion gap (AG) was determined to be 12 ± 4 meq/L. However, with introduction of the autoanalyzers using an ion-selective electrode (ISE), the anion gap value has fallen to lower levels. METHODS A retrospective study of US veterans from a single medical center was performed to determine the value of the anion gap in ...

with predialysis renal failure? Circulation 2000; 102: 871–875 36. Bayés B, Cruz Pastor M, Bonal J et al. Homocysteine, C-reactive protein, lipid peroxidation and mortality in haemodialysis patients. Nephrol Dial Transplant 2003; 18: 106–112 37. van Guldener C, Janssen MJ, Lambert J et al. No change in impaired endothelial function after long-term folic acid therapy of hyperhomocysteinaemia in ...

A 52yearold woman with endstage renal disease for chronic glomerulonephritis was started on inpatient peritoneal dialysis (PD). We increased infusion volume of PD exchange every 2 days without observing any symptoms, including respiratory symptoms. After changing infusion volume on the 5th day, the patient complained of dyspnea and continuous cough. Decreased breath sounds were noted in the rig...