Selkirk GA, McLellan TM, Wright HE, Rhind SG. Mild endotoxemia, NFB translocation, and cytokine increase during exertional heat stress in trained and untrained individuals. Am J Physiol Regul Integr Comp Physiol 295: R611–R623, 2008. First published June 18, 2008; doi:10.1152/ajpregu.00917.2007.—This study examined endotoxin-mediated cytokinemia during exertional heat stress (EHS). Subjects wer...

This study examined endotoxin-mediated cytokinemia during exertional heat stress (EHS). Subjects were divided into trained [TR; n=12, peak aerobic power (VO2peak)=70+/-2 ml.kg lean body mass(-1).min(-1)] and untrained (UT; n=11, VO2peak=50+/-1 ml.kg lean body mass(-1).min(-1)) groups before walking at 4.5 km/h with 2% elevation in a climatic chamber (40 degrees C, 30% relative humidity) wearing...

As important members of the innate immune response and conduits for induction of cell-mediated immunity, dendritic cells (DCs) have emerged as integral to understanding the immune response to pathogens. Due to their role in inflammation, ability to stimulate naïve T cells, and widespread presence in the body, the study of their physiological response is key to conceptualize immune function and ...