introduction: human adipose-derived mesenchymal stem cells (hadscs) are easily accessible in the body, and under appropriate conditions, they can be directed toward various phenotypes. therefore, hadscs have been considered as a potential cell source for tissue engineering applications. hadscs are able to differentiate into endothelial cells which covers the interior surface of vessels, in vivo...

introduction: proteolytic enzymes, specially collagenase, are used to digest extracellular matrix, cells isolation and primary culture. it is important to find new sources of plant or animal protease instead of bacterial or tissue collagenase. in the present research, actinidin, a plentiful protease in kiwifriut, was used to isolate human umbilical vein endothelial cells. materials and methods:...

oxidative stress has been implicated as a prominent determinant in the development of several diseases such as atherosclerosis. anti atherosclerotic effects of l-serine have been shown previously but its responsible mechanisms remained unidentified .this study aimed to investigate the antioxidant and cytoprotecrtive effects of l-serine and its possible mechanisms. for this purpose ,cell viabili...

background: marrow-derived mesenchymal stem cells (mscs) have been heralded as a source of great promise for the regeneration of the infarcted heart. there are no clear data as to whether or not in vitro differentiation of mscs into major myocardial cells can increase the beneficial effects of mscs. the aim of this study was to address this issue. methods: to induce mscs to transdifferentiate i...

objective(s): the aim of this study was to estimate effects of hyperbaric (hb) treatment by determination of cd15s and cd11b leukocyte proinflammatory markers expression.  in addition, this study describes changes in cd77 and cd34 expression on rat endothelial cells in renal, pulmonary and cardiac tissue following exposure to hyperbaric pressure. materials and methods:expression of cd11b and cd...

Background: Mesenchymal stem cells (MSCs) are multipotent cells, capable of differentiating into different cell lines.They can sense their surrounding biochemical and biophysical factors, which play major roles in their differentiation toward different phenotypes. Therefore, the exposure of these cells to endothelial growth factor (VEGF) as well as hemodynamic biomechanical forces, which act on...