Sporadic inclusion-body myositis (sIBM) is the most common disabling, adult-onset, inflammatory myopathy histologically characterized by intense inflammation and vacuolar degeneration. In spite of T cell-mediated cytotoxicity and persistent, clonally expanded and antigen-driven endomysial T cells, the disease is resistant to immunotherapies. Alemtuzumab is a humanized monoclonal antibody that c...

Introduction & Aim: The ethanol and aqueous extracts of Alhagi camelorum Fisch. (Fabaceae) whole plant, Scrophularia desertii Del. (Scrophulariaceae) whole plant and ethanol extracts of Echinophora platyloba DC. (Apiaceae) whole plant, Teucrium polium L. (Lamiaceae) whole plant and Berberis integerrima Bunge root b...

a {em 2-rainbow dominating function} (2rdf) of a graph $g$ is a function $f$ from the vertex set $v(g)$ to the set of all subsets of the set ${1,2}$ such that for any vertex $vin v(g)$ with $f(v)=emptyset$ the condition $bigcup_{uin n(v)}f(u)={1,2}$ is fulfilled, where $n(v)$ is the open neighborhood of $v$. the {em weight} of a 2rdf $f$ is the value $omega(f)=sum_{vin v}|f (v)|$. the {em $2$-r...

Dog is the main reservoir host of visceral leishmaniasis in Iran. The present study was carried out to investigate visceral leishmaniasis in owned dogs with dermal lesions in Mashhad, Khorasan Razavi province. Thirty- nine owned dogs with dermal lesions were selected. During study, four of dogs were euthanized. The dermal smears, blood and tissue samples were collected and examined using parasi...

High temperature requirement A1 (HtrA1) is a trypsin-fold serine protease implicated in the progression of age-related macular degeneration (AMD). Our interest in an antibody therapy to neutralize HtrA1 faces the complication that the target adopts a trimeric arrangement, with three active sites in close proximity. In the present study, we describe antibody 94, obtained from a human antibody ph...

        Ricin, the toxic lectin extracted from the castor bean plant (Ricinus communis), consists of an A chain (RTA) and a B chain (RTB). Anti-A chain Abs and anti-B chain Abs can neutralize toxins in vivo and in vitro via blocking the binding of the toxin to the cell. Also, RTB protein is able to serve as an antigen deliver to the mucosal immune system and act as an immunoad...

Background: Salmonella can cause serious human gastroenteritis and is frequently isolated from various food samples. The cell culturing, immunoassay, and polymerase chain reactions (PCR) are the current methods to detect such pathogenic agents. However, these methods are time-consuming and labor-intensive, and thus unavailable for rapid-monitoring of Salmonella</em...

BACKGROUND An increased prevalence of coeliac disease in patients with primary biliary cirrhosis has been recently reported. However, in other studies the association has not been confirmed. There have been no formal attempts to systematically evaluate patients with autoimmune cholangitis for coeliac disease. METHODS Sera from 62 patients with primary biliary cirrhosis, 17 with autoimmune cho...