Studies on the mechanisms of decidualization and endometriosis are often hampered by lack of primary endometrial cells. To facilitate in vitro studies, we established a human endometrial stromal cell line, KC02-44D, immortalized with human telomerase reverse transcriptase. Upon exposure to ovarian stimuli, KC02-44D cells showed similar cytoskeletal marker or gene expression and biochemical phen...

Lysophosphatidic acid (LPA) is a pleiotropic phospholipid molecule involved in inflammation, angiogenesis, would healing, and cancer invasion. Whereas serum lysophospholipase D activity increases in women with pregnancy, the role of LPA in pregnancy remains unclear. We investigated the expression of LPA receptors and function of LPA in endometrial stromal cells. Histologically normal endometriu...

We presented a case of mixed endometrial stromal sarcoma and smooth muscle cell tumor of the uterus with intravenous metastasis into the right heart. 50 hot mutated key genes of solid tumors were detected by next generation sequencing. The literature about the diagnostic and therapeutic strategies of the disease were reviewed.

Inhibins and activins are growth factors belonging to the transforming growth factor-beta) family and are known to influence cell proliferation and differentiation. Because transforming growth factor-beta is involved in physiological and tumoral changes of uterine tissues, the present study aimed to evaluate whether human normal and neoplastic endometrial and cervical epithelial cells express a...

BACKGROUND Endometriosis is a complex estrogen-dependent disease that is defined as the presence of endometrial gland and stroma outside the uterine cavity. Although the exact mechanism for the development of endometriosis remains unclear, there is a large body of research data and circumstantial evidence that suggests a crucial role of estrogen in the establishment and maintenance of this disea...

Being a family of scarce endometrial stromal tumor, low-grade endometrial stromal sarcoma (LGESS) is an uncommon malign neoplasm, whose occurrence outside the uterus, like peritoneum, is extremely rare in the absence of metastasis or invasion of a primary uterine neoplasm. Herein we present the patient of a 44-year-old woman with no specific discomfort and abdomen-related symptoms who underwent...

BACKGROUND Several studies have indicated that human pre-implantation embryo-derived chorionic gonadotropin (hCG) may influence the implantation process by its action on human endometrial epithelial and stromal cells. Despite reports indicating that hCG acts on these cells to affect the production of several cytokines and growth factors (e.g., MIF, IGF-I, VEGF, LIF, IL-11, GMCSF, CXL10 and FGF2...

BACKGROUND Our previous studies suggested that aberrant activation of Wnt/ß-catenin signaling might be involved in the pathophysiology of endometriosis. We hypothesized that inhibition of Wnt/ß-catenin signaling might result in inhibition of cell proliferation, migration, and/or invasion of endometrial and endometriotic epithelial and stromal cells of patients with endometriosis. OBJECTIVES T...

introduction low-grade endometrial stromal sarcoma (lg-ess) is a malignant intrauterine tumor that rarely presents with distant metastasis. simultaneous lung and cardiac metastases from lg-ess is also an extremely rare event. case presentation a 42-year-old woman presented with dyspnea and exercise intolerance. she had a history of hysterectomy and left salpingoophorectomy. she underwent second...

endometrial stromal sarcoma (ess) is a rare malignant tumor of the endometrium, occurring in the age group of 40–50 years. we report a case of low-grade ess in a 39-year-old woman, presenting as rapid enlargement of a uterine fibroid polyp associated with irregular and excessive vaginal bleeding. polypectomy followed by pan hysterectomy was performed. histopathological examination and immunohis...