We have previously reported that endometrial expression of matrix metalloproteinase (MMP)-26 mRNA comes to a maximum in the early secretory phase. Since tissue inhibitor of metalloproteinase (TIMP)-4 is a potent inhibitor of MMP-26, the objective of this study was to identify the pattern of TIMP-4 mRNA expression in the normal endometrial cycle. We also evaluated hyperplastic, pre-malignant (at...

Human uterine endometrium undergoes a complex pattern of changes in proliferation and secretory activity during the menstrual cycle. In the present study, telomerase activity in normal endometrium was examined using a non-radioisotope PCR-based telomeric repeat amplification protocol assay. Various levels of telomerase activity were detected in the 60 normal endometrial samples examined, depend...

Background Determination of the role of steroid hormones in expression and regulation of endometrial glucose transport 4 (GLUT4) in humans is important for understanding endometrial disorders such as polycystic ovary syndrome (PCOS), a common hormone-imbalance disease. Methods Endometrial biopsy samples were collected from non-PCOS patients with regular menstrual cycles or with hyperplasia and ...

Introduction: Colour Doppler has emerged as useful adjunct to transvaginal sonography in evaluation of women with AUB. This study was carried out evaluate the role measurement Resistance index (RI) and Pulsatility (PI) uterine arteries by discriminate between benign malignant endometrial condition abnormal bleeding.Material Methods: prospective analytical performed 70 (30-60 years) Spiral arter...

Diagnosis of endometrial intraepithelial neoplasia (EIN) requires learning new criteria. Two trainees rendered diagnoses based on biopsy findings, and then measured the effect of reviewing PAX2 on their interpretation. Fifty-two endometrial biopsy specimens diagnosed as having EIN were evaluated using EIN criteria. Background endometrial pattern, altered differentiation, and any features compli...

Uterine sarcomas account for 1% of female genital tract cancers and 2-5% of uterine malignancies (Major et al., 1993; Tavassoli & Devilee, 2003). This heterogenous group of tumors derives from uterine mesodermal tissue and because of their rarity and histopathological diversity, there is a lack of consensus on prognostic factors and optimal treatment. Uterine sarcomas were classified into 4 mai...

Dysfunctional uterine bleeding occurs in the absence of any pelvic pathology with disruption of normal patterns of endometrial stimulation. It is diagnosed by exclusion and is found more commonly in women around perimenopausal age and increases till menopause. Diagnosis is by histopathologic examination. Methods: Endometrial biopsies of 100 women in the reproductive and perimenopausal age were ...

In the pre-menopausal years, the ovarian secretion waxes and wanes until its cessation. In this study of women in the pre-menopausal period neither did the menstrual pattern prove to be a reliable criterion by which to judge the extent of oestrogen effect or deficiency nor was there correlation between serial colpocytology and endometrial histology, Hyperplasia of the endometrium was seen with ...

The majority of ovarian, endometrial, and breast cancers express gonadotropin-releasing hormone (GnRH) receptors. Apart from reproductive organs (ovaries, fallopian tubes, and uterus) that are normally removed during surgical therapy of ovarian or endometrial cancer, pituitary gonadotrophs also express GnRH receptors. The signal transduction pathway in tumor cells is basically different from th...