Synchronous endometrial and cervical cancer is a very rare condition. This report describes a case of a 46-year-old woman who presented with a cervical mass that measured 5.6 cm along its longest diameter, whose biopsy analysis revealed an endocervical mucinous adenocarcinoma. She was classified as having an IB2 cervical carcinoma and treated with concurrent chemoradiation plus hysterectomy. Pa...

OBJECTIVE To investigate the association of microcystic, elongated, and fragmented (MELF) pattern of invasion with prognostic factors in endometrioid endometrial adenocarcinoma (EEA). MATERIAL AND METHODS Stained tissue sections from 83 cases of EEA operated by the same gynecologic oncologist were reviewed to identify cases showing MELF-type invasion in this retrospective study. The associati...

Maspin is a member of the serpin family, whose expression is altered in neoplasia and malignancies of many tissues. Underexpression of maspin has been reported in breast and prostatic cancers, but in some cancers such as ovarian, colorectal and pancreatic carcinoma, it was found to be up-regulated. This study aimed at demonstrating the expression of maspin in human endometrial tissue and search...

PURPOSE Endometrial carcinoma is the most common gynecologic cancer in developed countries. Prolonged unopposed estrogen exposure has been identified as the major risk factor. The pi-class glutathione S-transferase (GSTP1) is a phase II metabolic enzyme that is important in the detoxification of a wide range of electrophiles including carcinogenic steroid-hormone intermediates generated through...

OBJECTIVE This study was undertaken to evaluate the ability of preoperative endometrial sampling to accurately diagnose high-grade endometrial tumors. STUDY DESIGN Three hundred sixty endometrial cancer patients had preoperative endometrial sampling and hysterectomy specimens that underwent pathologic review at a single institution from 1995 to 2005. The sensitivity of Pipelle and curettage t...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Stolnicu S, Podoleanu C, Orban I, Francisc R. Endometrial adenocarcinoma with gastrointestinal differentiation – a newly described entity, morphologic diversity. Polish Journal of Pathology. 2021;72(1):84-86. doi:10.5114/pjp.2021.106446. APA Stolnicu, S., Podoleanu, C., Orban, I., & Francisc, (2021). Pathology, 72...

Endometrial cancer Double uterus Histopathology Abstract We report a rare case of endometrial carcinoma arisen from both horns of an asymmetrical double uterus. Dr. Yoshiharu Tsukahara, Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto 390 (Japan) Introduction Although the incidence of a malformed uterus is not so rare, there have been few re...

PURPOSE To evaluate the toxic effects and antitumour activity of a multidrug regimen with cisplatin, epirubicin and paclitaxel (CEP) as initial therapy in patients with uterine adenocarcinoma. PATIENTS AND METHODS Forty-nine patients with histologically-confirmed diagnoses of locally advanced, recurrent or metastatic cervical or endometrial adenocarcinoma entered the study. Treatment consiste...