In 2010 all ECB publications feature a motif taken from the €500 banknote. and an anonymous ECB WPS referee for helpful comments and suggestions. The opinions expressed herein are those of the authors and do not necessarily reflect those of the ECB or the Eurosystem. Fax +49 69 1344 6000 All rights reserved. Any reproduction, publication and reprint in the form of a different publication, wheth...

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesics, but can cause gastric and esophageal hemorrhages, erosion, and ulceration. The endogenous cannabinoid (endocannabinoid; eCB) system possesses several potential targets to reduce gastric inflammatory states, including cannabinoid receptor type 1 (CB(1)), cannabinoid receptor type 2 (CB(2)), and enzymes that regulate the ...

Social affiliation is essential for many species and gains significant importance during adolescence. Disturbances in social affiliation, in particular social rejection experiences during adolescence, affect an individual's well-being and are involved in the emergence of psychiatric disorders. The underlying mechanisms are still unknown, partly because of a lack of valid animal models. By using...

the cannabinoidergic system acquired a reputation as the most abundant g-protein coupled receptor in the cns that acts as retrograde modulator of neurotransmitter release. recently, endocannabinoids (ecbs) have been highlighted as neurodevelopmental signaling cues that exert a regulatory role in brain development. the interruption in ecb system elements (including receptors and enzymes of synth...

In this paper we examine the representativeness of the EventCorefBank (ECB) (Bejan and Harabagiu, 2010) with regards to the language population of large-volume streams of news. The ECB corpus is one of the data sets used for evaluation of the task of event coreference resolution. Our analysis shows that the ECB in most cases covers one seminal event per domain, what considerably simplifies even...

Abstract Background Recent research indicates that endocanabinoids (eCB) and heart rate variability (HRV) are associated with stress-induced experiences. However, these underlying mechanisms have not been elucidated. Purpose The aim of the present study is to investigate if exposure acute chronic stress promotes measurable changes concurrently peripheral eCB ligands HRV. Methods 13 candidates u...

A separate WHO document intended to provide more detailed guidance on preclinical and laboratory evaluation of vaccines is in preparation. This was subsequently established by the 54th meeting, November 2003, of the WHO Expert Committee or Biological Standardization and is to be published in the WHO Technical Report Series. The section of this document that discusses preclinical and laboratory ...

Two deoxyglucose (DG) derivatives, (α,β)-2-deoxy-2-amino(ethylcarbamate)-D-glucose (ECB-DG) and (α,β)-2-deoxy-2-amino(1,2-dihydroxypropyl)-D-glucose (DHP-DG), were synthesized and radiolabeled successfully with [99mTc(H2O)3(CO)3]+ complex. [99mTc]-ECB-DG and [99mTc]-DHP-DG complexes were prepared (96% and 93% radiochemical purities respectively) by using 46 mCi of Na99mTcO4 in 1 mL saline. Radi...

NOTE: This Working Paper should not be reported as representing the views of the European Central Bank (ECB). The views expressed are those of the author and do not necessarily reflect those of the ECB. In 2011 all ECB publications feature a motif taken from the €100 banknote. Fax +49 69 1344 6000 All rights reserved. Any reproduction, publication and reprint in the form of a different publicat...

Endocannabinoid signaling in the dorsal raphe (DR) has recently been implicated in the regulation of anxiety and depression. However, the cellular mechanisms by which endocannabinoids (eCBs) regulate the excitability of DR 5-hydroxytryptamine (serotonin; 5-HT) neurons remain poorly understood. In the present study, using whole-cell recording from DR 5-HT neurons, we examined the effects of eCBs...