نتایج جستجو برای: endocannabinoid

تعداد نتایج: 3595  

Journal: :Neuroscience 2012
R J McLaughlin G Gobbi

The endocannabinoid system has recently emerged as a promising therapeutic target for the treatment of stress-related emotional disorders. A growing literature base has collectively demonstrated that facilitation of endocannabinoid signaling promotes antidepressant- and anxiolytic-like responses in preclinical animal models, while disruption of this system profoundly affects emotion, cognition,...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Laura C Gregg Kwang-Mook Jung Jessica M Spradley Rita Nyilas Richard L Suplita Andreas Zimmer Masahiko Watanabe Ken Mackie István Katona Daniele Piomelli Andrea G Hohmann

Acute stress reduces pain sensitivity by engaging an endocannabinoid signaling circuit in the midbrain. The neural mechanisms governing this process and molecular identity of the endocannabinoid substance(s) involved are unknown. We combined behavior, pharmacology, immunohistochemistry, RNA interference, quantitative RT-PCR, enzyme assays, and lipidomic analyses of endocannabinoid content to un...

2010
Hesham Khairy Wael E. Houssen

Since the first endocannabinoid anandamide was identified in 1992, extensive research has been conducted to characterize the elements of the tightly controlled endocannabinoid signaling system. While it was established that the activity of endocannabinoids are terminated by a two-step process that includes cellular uptake and degradation, there is still a continuing debate about the mechanistic...

Journal: :Asia-Pacific Journal of Oncology Nursing 2023

Cachexia-anorexia cancer syndrome remains an unmet clinical need with a dearth of treatment and no standard care. Acting through the endocannabinoid system, cannabinoids are one potential cachexia treatment. Herein mechanisms for discussed as previous ongoing trials.

Journal: :Gastroenterology 2003
Alessia Ligresti Tiziana Bisogno Isabel Matias Luciano De Petrocellis Maria Grazia Cascio Vittorio Cosenza Giuseppe D'argenio Giuseppe Scaglione Maurizio Bifulco Italo Sorrentini Vincenzo Di Marzo

BACKGROUND & AIMS The endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG) inhibit cancer cell proliferation by acting at cannabinoid receptors (CBRs). We studied (1). the levels of endocannabinoids, cannabinoid CB(1) and CB(2) receptors, and fatty acid amide hydrolase (FAAH, which catalyzes endocannabinoid hydrolysis) in colorectal carcinomas (CRC), adenomatous polyps, and neighboring...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Daniel R McDougle Josephine E Watson Amr A Abdeen Reheman Adili Megan P Caputo John E Krapf Rodney W Johnson Kristopher A Kilian Michael Holinstat Aditi Das

Clinical studies suggest that diets rich in ω-3 polyunsaturated fatty acids (PUFAs) provide beneficial anti-inflammatory effects, in part through their conversion to bioactive metabolites. Here we report on the endogenous production of a previously unknown class of ω-3 PUFA-derived lipid metabolites that originate from the crosstalk between endocannabinoid and cytochrome P450 (CYP) epoxygenase ...

2014
Roger G. Pertwee

The endocannabinoid system consists of cannabinoid CB1 and CB2 receptors, of endogenous agonists for these receptors known as ‘endocannabinoids’, and of processes responsible for endocannabinoid biosynthesis, cellular uptake and metabolism. There is strong evidence first, that this system up-regulates in certain disorders as indicated by an increased release of endocannabinoids onto their recep...

2014
Eduardo Blanco Francisco J. Pavón Ana Palomino María Jesús Luque-Rojas Antonia Serrano Patricia Rivera Ainhoa Bilbao Francisco Alen Margarita Vida Juan Suárez Fernando Rodríguez de Fonseca

BACKGROUND Endocannabinoids modulate the glutamatergic excitatory transmission by acting as retrograde messengers. A growing body of studies has reported that both signaling systems in the mesocorticolimbic neural circuitry are involved in the neurobiological mechanisms underlying drug addiction. METHODS We investigated whether the expression of both endocannabinoid and glutamatergic systems ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
Shi Di Christy A Itoga Marc O Fisher Jonathan Solomonow Emily A Roltsch Nicholas W Gilpin Jeffrey G Tasker

UNLABELLED Stress and glucocorticoids stimulate the rapid mobilization of endocannabinoids in the basolateral amygdala (BLA). Cannabinoid receptors in the BLA contribute to anxiogenesis and fear-memory formation. We tested for rapid glucocorticoid-induced endocannabinoid regulation of synaptic inhibition in the rat BLA. Glucocorticoid application to amygdala slices elicited a rapid, nonreversib...

Journal: :Pharmacological reviews 2006
Pál Pacher Sándor Bátkai George Kunos

The recent identification of cannabinoid receptors and their endogenous lipid ligands has triggered an exponential growth of studies exploring the endocannabinoid system and its regulatory functions in health and disease. Such studies have been greatly facilitated by the introduction of selective cannabinoid receptor antagonists and inhibitors of endocannabinoid metabolism and transport, as wel...

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