The separation of an enantiomer from a racemic mixture is of primary relevance to the pharmaceutical industry. The thermochemical properties of organic enantiopure and racemate crystals can be exploited to design an enantioselective crystallization process. The thermodynamic difference between the two crystal forms is accessible by two cycles which give the eutectic composition in solution. The...

An efficient chiral separation membrane was fabricated from bovine serum albumin (BSA) modified graphene oxide (GO), BSA linked with GO through EDC/NHS coupling chemistry. This can successfully separate Phe racemate, and the excess enantiomer (ee) in osmotic solution up to 96.1% under optimal conditions. We found that addition of not only enlarged spacing but also formed channels selective tran...

Reported herein is the first enantioselective method for simultaneous separation of chiral pharmaceuticals and pesticides using ultra-high-performance liquid chromatography-tandem mass spectrometry. Separation was achieved a ChiralPak IG-U® column (amylose tris(3-chloro-5-methylphenylcarbamate) stationary phase) ethanol as ‘green’ mobile phase organic modifier. Minimum enantiomer resolutions ra...

PF74 is a capsid-targeting inhibitor of HIV replication that effectively perturbs the highly sensitive viral uncoating process. A lack information regarding optical purity (enantiomeric excess) single stereogenic centre has resulted in ambiguity as to potency different samples this compound. Herein described synthesis enantiomerically enriched (S)- and (R)-PF74 further enrichment (≥98%) using c...

Sphingomonas herbicidovorans MH (previously designated Flavobacterium sp. strain MH) was able to utilize the chiral herbicide (RS)-2-(4-chloro-2-methylphenoxy)propionic acid (mecoprop) as the sole carbon and energy source. When strain MH was offered racemic mecoprop as the growth substrate, it could degrade both the (R) and the (S) enantiomer to completion, as shown by biomass formation, substr...

BACKGROUND Although it is accepted widely that optically active intravenous general anesthetics produce stereoselective effects in animals, the situation regarding volatile agents is confused. Conventional studies with scarce isoflurane enantiomers have been limited to small numbers of animals and produced conflicting results. By injecting these volatile enantiomers intravenously, however, it i...

Enantiomers of chiral biomolecules and drugs have distinct pharmacological and toxicological activities. . Consequently, separation and determination of enantiomers are vital in pharmaceutical and chemical industries. It is wellknown that the l-enantiomer of oligopeptides naturally exists in the organism; however, d-oligopeptides are regarded as potential therapeutic agents because of their res...