Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by proliferation of one or more myeloid cell lineages. Some patients exhibit leukemic transformation (LT) by unknown mechanisms, and chemotherapy may increase the risk of LT. To clarify the molecular mechanisms of LT, gene alterations involved in LT from patients in the chronic phase (CP) of MPNs were...

Introduction. Model for end-stage liver disease (MELD) is an accurate predictor of mortality in patients with cirrhosis, and has been used on liver allocation in Brazil since 2006. However, its impact on organ allocation, waiting list and post-transplant mortality is still poorly characterized. This study aimed to assess the impact of implementation of the MELD system on liver allocation and mo...

We study short period gravity waves (20–120 min) in the equatorial Mesosphere and Lower Thermosphere (MLT) using a Medium Frequency (MF) radar at Pameungpeuk (7.4 S, 107.4 E), Indonesia. In particular, we study local time and seasonal variation of the gravity wave variance and its relation to tropical convection. The gravity wave variance at 88 km enhances between 20:00 LT and 07:00 LT, with a ...

Gap junctions (GJs) exhibit a complex modus of assembly and degradation to maintain balanced intercellular communication (GJIC). Several growth factors, including vascular endothelial growth factor (VEGF), have been reported to disrupt cell-cell junctions and abolish GJIC. VEGF directly stimulates VEGF-receptor tyrosine kinases on endothelial cell surfaces. Exposing primary porcine pulmonary ar...

Gap junctions (GJs) between neurons are present in both the newborn and the adult nervous system, and although important roles have been suggested or demonstrated in a number of instances, in many other cases a full understanding of their physiological role is still missing. GJs are expressed in the rodent lumbar cord at birth and mediate both dye and electrical coupling between motor neurons. ...

Gap junctions (GJs) are not static bridges; instead, GJs as well the molecular building block connexin (Cx) proteins undergo major expression changes in degenerating retinal tissue. Various progressive diseases, including retinitis pigmentosa, glaucoma, age-related degeneration, etc., affect neurons of retina and thus their neuronal connections endure irreversible well. Although Cx might be hal...

Situs inversus totalis (SIT) is a rare congenital anomaly, and liver transplantation (LT) in an adult SIT patient is extremely rare. Liver transplantation in a SIT patient is also technically challenging due to reversed anatomical structures. Here we present the case of an 18-year-old female with SIT in whom left lobe living donor LT was performed. The patient suffered from cirrhosis due to aut...

Introduction Charcot–Marie–Tooth disease (CMT) encompasses a group of mostly non-syndromic inherited peripheral motor and sensory neuropathies, which are genetically heterogeneous and have a prevalence of ϳ17– 40:100,000 world-wide— one of the most common neuro-genetic disorders (Martyn and Hughes, 1997). The X-linked form of CMT (CMT1X) is the second most common form among all CMT patients wit...

1. Benzolamide is a poorly permeant sulfonamide inhibitor of the enzyme carbonic anhydrase. We studied the effect of benzolamide on low-threshold (LT) Ca currents in neonatal hippocampal CAl neurons. 2. In hippocampal slices, benzolamide (2-10 microM) inhibited the LT current 30-75% in voltage-clamped CAl pyramidal cells (n = 6). In slices bathed in N-2-hydroxypiperazine-N'-2-ethane-sulfonic ac...