نتایج جستجو برای: embryotoxicity introduction
تعداد نتایج: 376702 فیلتر نتایج به سال:
Background: Bendiocarbamate is a carbamate insecticide, which belongs among the cholinesterase inhibitors. Cholinesterase inhibitors is a group of chemical compounds, which inhibits acetylcholine hydrolysis by acetylcholinesterase, thereby acetylcholine accumulates in the reactive locations of a living organism. Objective: The aim of the study was to investigate toxicity dose of bendiocarbamate...
The embryotoxic potential of the commonly used fungicide, methyl 2-benzimidazolecarbamate (MBC) was evaluated in rat and hamster embryo limb bud (LB) and midbrain (CNS) cell micromass cultures. Cultures were exposed to seven concentrations of 0.03, 0.12, 0.49, 1.95, 7.81, 31.25 and 125 μg MBC/ml. Developmental toxicity was assessed via the following parameters: cytotoxicity, by quantifying neut...
OBJECTIVES Resin (co)monomers may be released from restorative dental materials and can diffuse into the tooth pulp or the gingiva, and can reach the saliva and the circulating blood. Genotoxic potential of some dental composite components has been clearly documented. The genotoxic effects of xenobiotics can represent a possible step in tumor initiation and/or embryotoxicity/teratogenesis. A mo...
Although the biokinetics, metabolism, and chemical toxicity of atorvastatin calcium are well known, until recently little attention was paid to the potential toxic effects of atorvastatin calcium on re-production and development in mammals. In recent years, it has been shown that atorvastatin calcium is a developmental toxicant when given orally or subcutaneously (SC) to mice. Decreased fertili...
Many industrial chemicals and their respective by-products need to be comprehensively evaluated for toxicity using reliable and efficient assays. In terms of teratogenicity evaluations, the murine-based embryonic stem cell test (EST) offers a promising solution to screen for multiple tissue endpoints. However, use of a mouse model in the EST can yield only a limited understanding of human devel...
Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites. Artemisinins are embryotoxic in animal models and induce apoptosis in sensitive mammalian cells. Understanding the cytotoxic propensities of a...
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