نتایج جستجو برای: embryonal rhabdomyosarcoma
تعداد نتایج: 24466 فیلتر نتایج به سال:
Connective tissue growth factor (CTGF/CCN2), a cysteine-rich protein of the CCN (Cyr61, CTGF, Nov) family of genes, emerged from a microarray screen of genes expressed by human rhabdomyosarcoma cells. Rhabdomyosarcoma is a soft tissue sarcoma of childhood deriving from skeletal muscle cells. In this study, we investigated the role of CTGF in rhabdomyosarcoma. Human rhabdomyosarcoma cells of the...
Rhabdomyosarcomas derive from the skeletal muscle lineage and harbor a variety of genetic and molecular lesions. However, it is not clear which molecular alterations have a pathogenetic role. We show that activation of the HER-2/neu oncogene coupled with inactivation of the oncosuppressor gene p53 causes rhabdomyosarcoma in mice. At the age of 11-21 weeks, all male mice carrying both genetic le...
We present a 2 year-old boy with a botryoid type of embryonal nasopharyngeal rhabdomyosarcoma with an unusual outcome. Temporal bone metastasis with brain invasion was detected one year after therapy had been completed. Despite multidisciplinary therapeutic approach, distant metastases occurred in the mastoid and squamous portions of the temporal bone with invasion of the temporal lobe. We revi...
We describe a 16-year-old boy with rhabdomyosarcoma, consistent with embryonal subtype, of the lower extremity who received systemic neoadjuvant chemotherapy and subsequent excision. Microscopic sections of the postchemotherapy excision demonstrated diffuse, prominent, and immature adipocyte-like differentiation, in addition to skeletal muscle differentiation. Adipocyte-like differentiation was...
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