Malaria (vector: Anopheles gambiae) is a major infectious disease that kills about 1 million people each year. For the improvement of its treatment and vector control during the past decades, several issues such as high medicine cost, insecticide resistance, and lack of an effective vaccine have prevented adequate control of malaria. Additionally, the low selectivity of malaria vector insectici...

Cereal Chem. 70(1):22-26 A direct colorimetric method that simultaneously combines measurematerial, absorbance at 412 nm was read. This assay was highly reproment of solubilized and insoluble thiol groups and disulfide bonds in ducible, and measurements agreed with direct amino acid analysis. Twincorn meal-based materials is described. Ellman's reagent, 5,5'-dithiobis screw extrusion of corn me...

The design, development and application of an efficient procedure for the concise synthesis of the 1,3-syn- and anti-tetrahydropyrimidine cores of manzacidins are reported. The intramolecular allylic substitution reaction of a readily available joint urea-type substrate enables the facile preparation of both diastereomers in high yields. The practical application of this approach is demonstrate...

A Pichia pastoris (P. pastoris) cell surface display system of Bombyx mori acetylcholinesterase (BmAChE) was constructed and its bioactivity was studied. The modified Bombyx mori acetylcholinesterase gene (bmace) was fused with the anchor protein (AGα1) from Saccharomyces cerevisiae and transformed into P. pastoris strain GS115. The recombinant strain harboring the fusion gene bmace-AGα1 was in...

Rotator cuff tears are a common cause of shoulder pain and dysfunction that affect all kinds of people, from sedentary individuals to elite athletes. Surgical repair of rotator cuff tears aims to re-establish the shoulder’s normal anatomical structure with restoration of pain-free motion, strength, and function. Rotator cuff repair (RCR) has evolved from an all-open procedure to an arthroscopic...

Alzheimer hastalığı (AD), beyinde asetilkolin üreten veya kullanan kolinerjik hücrelerin yıkımı kaybından kaynaklanmaktadır. Bundan dolayı, AD için ana tedavi stratejisi beyindeki seviyesini arttırmaktır.
 Bu çalışmada, kolinesteraz inhibitörleri olarak yeni tiyazol-hidrazinil türevlerinin sentezi gerçekleştirilmiştir. Sentezlenen bileşiklerin yapısı 1H-NMR ve 13C-NMR verileri ile aydınlat...

AIM To investigate the potential tissue-protective effects of antioxidants selenomethionine and D-pantethine applied together with doxorubicin (Dx) on NK/Ly lymphoma-bearing mice. The impact of this chemotherapy scheme on animal survival, blood cell profile, hepatotoxicity, glutathione level, and activity of glutathione-converting enzymes in the liver was compared with the action of Dx applied ...

Clinical reports suggest a positive association between fat consumption and the incidence of hyperactivity, impulsivity and cognitive abnormalities. To investigate possible mechanisms underlying these disturbances under short-term conditions, we examined in Sprague-Dawley rats the influence of 7-day consumption of a high-fat diet (HFD) compared to chow on anxiety, novelty-seeking and explorator...

* The work described in this paper was sponsored by the U.S. Atomic Energy Commission. t On leave of absence from the Department of Biochemistry, University College, London. 1 Rabin, B. R., and P. W. Trown, these PROCEEDINGS, 51, 497 (1964). 2 Ellman, G. L., Arch. Biochem. Biophys., 82, 70 (1959). 3Rabin, B. R., D. F. Shaw, N. G. Pon, J. M. Anderson, and M. Calvin, J. Am. Chem. Soc., 80, 2528 (...