PURPOSE Pressure-induced ocular ischemia is a frequent model for the investigation of the mechanisms and therapy of retinal ischemic damage. It is important to know whether the tissue damage in such experiments is uniform or irregular. METHODS We reviewed histologic features of Dutch rabbit eyes after 60-80 min of pressure-induced ischemia. The eyes were enucleated 4 hr, 1 day, or 1 wk after ...

A SIGNAL CONDITIONING APPROACH FOR THE EXTRACTION OF THE OSCILLATORY POTENTIAL FROM THE ELECTRORETINOGRAM by Peter Haines Derr The oscillatory potential (OP), a signal component of the electroretinogram (ERG), was investigated to determine correlation of the OP and pathological conditions of the inner retina. Large transients characterize the ERG. Such transients stimulate a filter's natural re...

OBJECTIVE To determine the efficacy of intravitreal administration of 9-cis-retinal in restoring visual function in Rpe65-mutant dogs. METHODS Intravitreal injection of 9-cis-retinal was administered in 1 eye of 7 Rpe65-/- dogs at a range of ages. Electroretinogram analysis and testing of visual performance was used to evaluate outcomes after a single injection and in 2 dogs after a second in...

The electroretinogram (ERG) was obtained to contrast modulation (CM). This stimulus is a product of temporal modulation of the contrast of a spatial sinusoid at constant mean luminance. Mean contrast (10-40%), and modulation depth (25-1.0) were modulated at 7.5Hz to record the pattern electroretinogram (PERG). The spatial pattern was a foveally fixated grating pattern with sinusoidal luminance ...

A better understanding of the visual attraction of house ßies to colors and patterns is needed to improve ßy trap performance. This study combined physiological responsesmeasuredwith electroretinogram studies of the house ßyÕs compound eyes and ocelli with behavioral attraction of ßies to reßective colors and patterns in light tunnel assays. Compound eye and ocellar electroretinogram responses ...

AIM To investigate the cause of visual loss following removal of intraocular silicone oil in patients who underwent vitrectomies for retinal detachment or giant retinal tear. METHODS The clinical records of three cases with visual loss following removal of silicone oil were reviewed. Investigations carried out included fundus fluorescein angiogram, optical coherence tomography, and electrophy...

Endoplasmic reticulum stress has been reported to be involved in the pathogenesis of retinitis pigmentosa, macular degeneration and diabetic retinopathy. In the present study, we examined the effects of deferiprone, an iron chelator, on photoreceptor degeneration induced by tunicamycin (300 nmol/eye), an endoplasmic reticulum stress inducer, in the rat retina. Scotopic electroretinogram measure...

SINCE Adrian and Matthews (1928) showed that the latent period of the optic nerve discharge can be influenced by the size of the area stimulated, the effect of area on the electroretinogram has been confirmed by a number of workers (Granit, 1933; Creed and Granit, 1933; Fry and Bartley, 1935; Boynton and Riggs, 1951). The size and shape of the electroretinogram can be influenced in the same way...