Gregory D. D. Hurst1*, Francis M. Jiggins2, J. Hinrich Graf von der Schulenburg2, Dominique Bertrand2, Stuart A. West3, Irina I. Goriacheva4, Ilia A. Zakharov4, John H. Werren5, Richard Stouthamer6 and Michael E. N. Majerus2 1Department of Biology, University College London, 4 StephensonWay, London NW1 2HE, UK 2Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, ...

Epidermal growth factor receptor tyrosine kinase substrate 15 (Eps15) homology (EH)-domain proteins can be divided into two classes: those with an N-terminal EH-domain(s), and the C-terminal Eps15 homology domain-containing proteins (EHDs). Whereas many N-terminal EH-domain proteins regulate internalization events, the best characterized C-terminal EHD, EHD1, regulates endocytic recycling. Beca...

PURPOSE Based on the hypothesis that oral nutraceuticals do not adequately reach all ocular tissues in the anterior segment, we evaluated the ability of a 3% concentration of the ingredients in a topical nutraceutical antioxidant formulation called Optixcare Eye Health (Optixcare EH) to ameliorate oxidative stress in rat models of age-related ocular diseases. METHODS Diabetes was induced by t...

1 Introduction Energy harvesting (EH) research area has been emerged to build self-powered wireless electrical devices such as wireless sensors by collecting ambient or wasted energy. This EH technology is highly demanding because wireless sensors are increasingly used in the areas of structural health monitoring (SHM), building automation, and so on. The battery, a current power source for wir...

cis-9,10-epoxystearic acid was used as a tool to probe the active sites of epoxide hydrolases (EHs) of mammalian and plant origin. We have compared the stereochemical features of the hydrolysis of this substrate catalysed by soluble and membrane-bound rat liver EHs, by soluble EH (purified to apparent homogeneity) obtained from maize seedlings or celeriac roots, and by recombinant soybean EH ex...

BACKGROUND We conducted this systematic review and meta-analysis to evaluate the association between essential hypertension (EH) and bone mineral density (BMD). RESULTS 17 articles were included in our meta-analysis, with a total of 39,491 patients. Of these, 13,375 were patients with EH and 26,116 were patients without EH. Meta-analysis results showed that EH can reduce the BMD of the lumbar...

This paper proposes a new combination of quantitative models and Genetic Algorithms for the task of optimising credit portfolios. Currently, quantitative portfolio credit risk models are used to calculate portfolio risk figures, e. g. expected losses, unexpected losses and risk contributions. Usually, this information is used for optimising the risk-return profile of the portfolio. We show that...

European consumer credit markets are still highly segmented: they differ in credit culture, composition and regulation. The new Consumer Credit Directive is intended to establish a maximal harmonization within member states to further increase integration. But is the Directive in its proposed version an adequate instrument to achieve this goal? To approach this question, the present position pa...

Dopamine has been shown to influence renal sodium excretion through a direct interaction with the dopamine receptor (DR). The dopamine D1 receptor (DRD1) has been localized to the proximal tubules and is known to increase sodium excretion by inhibiting Na-H exchanger and Na,K-ATPase activity. Defective renal dopamine production and/or DR function have been reported in essential hypertension (EH...