The heart is richly endowed with K(ATP) channels, which function as biological sensors, regulating membrane potentials and electrical excitability in response to metabolic alterations. We recently reported that the cytochrome P450 metabolites of arachidonic acid, epoxyeicosatrienoic acids (EETs), potently activate cardiac K(ATP) channels by reducing channel sensitivity to ATP. In the present st...

Extracellular electron transfer (EET) is a microbial metabolism that enables efficient electron transfer between microbial cells and extracellular solid materials. Microorganisms harbouring EET abilities have received considerable attention for their various biotechnological applications, including bioleaching and bioelectrochemical systems. On the other hand, recent research revealed that micr...

OBJECTIVE Epoxyeicosatrienoic acids (EETs) serve as endothelial-derived hyperpolarizing factors (EDHF), but may also affect vascular function by other mechanisms. We identified a novel interaction between EETs and endothelial NO release using soluble epoxide hydrolase (sEH) -/- and +/+ mice. METHODS AND RESULTS EDHF responses to acetylcholine in pressurized isolated mesenteric arteries were n...

Epoxyeicosatrienoic acid (EET) is a cardioprotective metabolite of arachidonic acid. It is known that soluble epoxide hydrolase (sEH) is involved in the metabolic degradation of EET. The abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) play important roles in the pathogenesis of atherosclerosis and restenosis. Thus, the present study investigated the effects of the s...

An effective environmental temperature (EET) developed for newborn piglets describes the thermal environment by incorporating the mean radiant temperature, dry-bulb temperature, and air velocity near the newborn. The adequacy of the defined EET was analyzed by comparing with three published studies on newborn sensible heat loss. Results from the published studies indicate that the EET predicted...

This systematic literature review (SRL) examines the impact of English educational tourism (EET) on growth local Small-Medium Enterprises (SMEs). Through a comprehensive search academic databases and assessment study quality, total 49 studies were selected for inclusion. The varied in design, location, intervention, but all focused relationship between SMEs. SLR focuses typology SMEs EET, its r...

Epoxyeicosatrienoic acids (EETs), synthesized from arachidonic acid by cytochrome P450 epoxygenases, are converted to dihydroxyeicosatrienoic acids by soluble epoxide hydrolase. EETs exert anti-inflammatory effects. However, the effect of EETs on humoral immunity is poorly understood. The present study is to investigate the potential role of EETs on B cell function and mechanisms. We examined t...

In this contribution we report on ERS-ENVISAT Tandem (EET) cross-interferometry (CInSAR) results achieved over Egypt. Over the Nile Delta an EET pair with a perpendicular baseline of 1948m was used to generate a DEM. Thanks to the long perpendicular baseline EET CInSAR showed a good potential to generate accurate DEMs over this relatively flat landscape. The result achieved is compared with the...

Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four epoxyeicosatrienoic acid (EET) regioisomers, 5,6-, 8,9-, 11,12-, and 14,15-EET, that function as autacrine and paracrine mediators. EETs produce vascular relaxation by activating smooth muscle large-conductance Ca2+-activated K+ channels (BKCa). In addition, they have anti-inflammatory effects on blood vessels and in the kidney...

We demonstrated previously that cytochrome P-450 (CYP) 2C29 is the epoxyeicosatrienoic acid (EET) synthase responsible for the EET-mediated flow/shear stress-induced dilation of vessels of female nitric oxide (NO)-deficient mice (Sun D, Yang YM, Jiang H, Wu H, Ojami C, Kaley G, Huang A. Am J Physiol Regul Integr Comp Physiol 298: R862-R869, 2010). In the present study, we aimed to identify whic...