• The anti-oxidative stress treatment is a crucial therapeutic strategy for ischemic stroke. CuATSM showed strong antioxidative and neuroprotective effects in acute These was enhanced by the combination with edaravone. therapy of edaravone may provide new effective stroke patients future. Cu-diacetyl-bis (N4-methylthiosemicarbazone) (CuATSM) has both anti-inflammatory activities, but its effica...

Direct bypass procedures effectively improve cerebral hemodynamics immediately after surgery in patients with moyamoya disease (MMD). However, they carry the risk of postoperative hyperperfusion that could lead to neurological deficits. We reported previously that hyperperfusion-related transient neurological deficits (TNDs) occurred in 31.5% of adult patients who underwent direct bypass proced...

BACKGROUND Defective interdomain interaction within the ryanodine receptor (RyR2) seems to play a key role in the pathogenesis of heart failure, as shown in recent studies. In the present study we investigated the effect of oxidative stress on the interdomain interaction, its outcome in the cardiac function in heart failure, and the possibility of preventing the problem with antioxidants. MET...

Abstract Introduction Sudden-onset quadriplegia is a neurologic emergency that requires immediate management. Anterior spinal artery syndrome (ASAS) rare, but can cause sudden-onset quadriplegia. Magnetic resonance imaging (MRI) an essential modality for diagnosing ASAS. Case Presentation A 31-year-old woman without previous medical history was transferred to our facility further workup of neck...

BACKGROUND In acute stage of cerebral infarction, MRI indices (rDWI & rADC) deteriorate during the first 3-7 days after the ictus and then gradually normalize in approximately 10 days (pseudonormalization time), although the tissue is already infarcted. Since effective treatments improve these indices significantly and in less than the natural pseudonormalization time, a combined analysis of th...

We previously found that oxygen-glucose-serum deprivation/restoration (OGSD/R) induces apoptosis of spinal cord astrocytes, possibly via caspase-12 and the integrated stress response, which involves protein kinase R-like endoplasmic reticulum kinase (PERK), eukaryotic initiation factor 2-alpha (eIF2α) and activating transcription factor 4 (ATF4). We hypothesized that edaravone, a low molecular ...

There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease. We established a multi-tiered platform for the sequential screening of drugs that could be repurposed as remyelinating agents. We screened a library of 2,000 compounds (mainly Food and Drug Administration (FDA)-approved compounds an...

BACKGROUND Two new neuro-protective agents, Edaravone and Citicoline were recently found to be beneficial in acute ischemic stroke (AIS). But there is no study to compare these two agents on same protocol in AIS. This study was aimed to compare these two neuroprotective agents in AIS. METHODS All patients of age more than 18 years who presented within 24 hours of acute ischemic stroke were ra...

OBJECTIVE it is hypothesized that free radical reactions evoked by oxyhemoglobin (oxyHb) cause cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH), even though the detailed mechanisms have not yet been fully established. The aims of this study were thus to investigate, through the use of the double-hemorrhage rabbit model, the possibility that free radical reactions play a role in...