Sinus node dysfunction in patients after repair of the secundum atrial septal defect has been ascribed to surgical damage. We studied 15 consecutive patients with secundum atrial septal defect before operative intervention. Noninvasive testing included 34-hour electrocardiographic monitoring and a standard 13-lead ECG. Intracardiac electrophysiologic techniques included corrected sinus node rec...

The basic helix-loop-helix transcriptional repressor Hairy-related transcription factor 2 (Hrt2) is expressed in ventricular, but not atrial, cardiomyocytes, and in endothelial and vascular smooth muscle cells. Mice homozygous for a null mutation of Hrt2 die perinatally from a spectrum of cardiac abnormalities, raising questions about the specific functions of this transcriptional regulator in ...

Left ventricular noncompaction (LVNC) is a rare disease caused by intrauterine failure of the myocardium to compact. The major clinical manifestations of LVNC include heart failure, ventricular tachyarrhythmia, thromboembolic event, and sudden deaths. Atrial arrhythmia usually seen is atrial fibrillation. We report a rare case of focal left atrial tachycardia in an 18-year-old patient who prese...

Reliable computer arrhythmia diagnosis is mostly restricted to ventricular arrhythmias because information about atrial activation cannot be reliably obtained from surface lead electrocardiograms (ECGs) [1,2,3]. A two channel computer arrhythmia detection system has been designed and successfully tested on a data base of a simultaneous esophageal electrograms and surface lead ECGs. The system h...

Experiments were performed on the hearts of open-chest anesthetized dogs and on isolated rabbit hearts. Intracellular microelectrodes and bipolar surface electrodes were used for recording from and for stimulating the atria, AV node, bundle of His, bundle branches and ventricles. Atrial or ventricular premature beats which were usually blocked or delayed within the AV node were facilitated when...