The Epstein-Barr Virus (EBV) is consistently found in tumor cells of Burkitt's lymphoma (BL) endemic in central Africa and malaria is considered a pathogenic cofactor. In contrast, fewer than 20% of BL cases occurring in Western countries are EBV-associated. We have investigated 54 BL cases from Bahia, a tropical region of Northeast Brazil, for expression of EBV gene products by in situ hybridi...

A variety of virus-based infectious diseases cause a host of problems for human health. Humans have developed a variety of defenses against viral infection, but unfortunately viruses have evolved clever and sophisticated ways to elude host cell defenses. The protein kinase R (PKR) plays a variety of important functions in a cell, but most importantly PKR is able to sense viral byproducts (dsRNA...

The aim of this study was to investigate the role of renal Epstein-Barr virus (EBV) infection in the pathogenesis of lupus nephritis (LN). A total of 58 renal tissue samples from patients with LN, seven normal renal tissue samples from patients with non-glomerular hematuria and 37 renal tissue samples from patients with minimal change nephropathy were collected. The expression of EBV-latent mem...

Periapical granulomas are lesions around the apex of a tooth caused by a polymicrobial infection. Treatment with antibacterial agents is normally performed to eliminate bacteria from root canals; however, loss of the supporting alveolar bone is typically observed, and tooth extraction is often selected if root canal treatment does not work well. Therefore, bacteria and other microorganisms coul...

A 78-year-old woman presented with generalized lymphadenopathy, fever and weight loss. A biopsy showed diffuse large B cell lymphoma (DLCL) without marrow involvement. Her serum lactate dehydrongenase (LDH) level was elevated (2110 IU/l, normal 200-440) and a computerized tomogram (CT) scan showed extensive intrathoracic and intrabdominal lymph nodes with no hepatosplenomegaly. The lymphoma exp...

OBJECTIVES To determine the pathogenic association of latent Epstein-Barr virus (EBV) infections with both typical hydroa vacciniforme (HV) and severe HV-like eruptions, and to survey the complications and outcomes of patients. DESIGN Case series. PATIENTS Twenty-nine patients with HV or severe HV-like eruptions. INTERVENTIONS In situ hybridization and immunostaining of biopsy specimens; ...

Epstein-Barr virus (EBV) has been implicated in the etiology of a large number of malignancies. Most recently several studies have linked EBV to Hodgkin's disease. In this report, formalin-fixed, paraffin-embedded tissues were collected retrospectively from 41 children with Hodgkin's disease treated at our hospital. Lymph node biopsies were examined for the presence of two virus-encoded latent ...