Bortezomib is a proteasome inhibitor used for hematologic cancer treatment. Since it can suppress NF-κB activation, which is critical for the inflammatory process, bortezomib has been found to possess anti-inflammatory activity. In this study, we evaluated the effect of bortezomib on experimental autoimmune uveitis (EAU) in mice and investigated the potential mechanisms related to NF-κB inactiv...

Experimental autoimmune uveoretinitis (EAU) was transferred into naive male Lewis rats using 1 X 10(8) indium-111 labeled lymphocytes from syngeneic donors immunized with S-antigen. The migration of the lymphocytes was monitored by gamma camera imaging and by determining the accumulation of radioactivity in selected organs. The majority of the cells leave the peritoneal cavity within 24 hr and ...

We report here identification of novel mimicry epitopes for interphotoreceptor retinoid-binding protein (IRBP) 201–216, a candidate ocular antigen that causes experimental autoimmune uveoretinitis (EAU) in A/J mice. One mimicry epitope from Ehrlichia canis (EHC), designated EHC 44–59, induced cross-reactive T cells for IRBP 201–216 capable of producing T helper (Th)1 and Th17 cytokines, but fai...

A combination of Classics, Egyptology, and experimental archaeology were utilized to recreate the (in)famous perfume used by Queen Cleopatra VII. Especially important was use classical sources paleobotany determine identity Egyptian sacred oils such as camphor balanos. Excavations at site Tell Timai revealed a perfumery that contributed our ability process manufacture. This ancient “Mendesian” ...

Management of American eels (Anguilla rostrata) requires an understanding of how demographic attributes vary within large estuaries. Yellow-phase American eel length and age structure, growth, dispersal, nematode infestation rates, loss rate (natural mortality and emigration), and production were measured at six sites throughout the tidal portion of the Hudson River. Short-term dispersal was lo...

PURPOSE The peroxisome proliferator-activated receptor α (PPARα) agonist has been approved for treating hypercholesterolemia and lipid abnormalities. Researchers have recently discovered that an anti-inflammatory effect of PPAR agonist may have the potential to treat autoimmune disease. This study aims to investigate the therapeutic effects of fenofibrate on experimental autoimmune uveoretiniti...

Mortality after Liver Transplantation (LT) for Hilar Cholangiocarcinoma (CCA) Poornima Ramanan, MD; Nathan W. Cummins, MD; Mark P. Wilhelm, MD; Julie K. Heimbach, MD; Ross Dierkhising; Walter Kremers, PhD; Charles B. Rosen, MD; Gregory J. Gores, MD; Raymund R. Razonable, MD; Mayo Clinic, Rochester, MN; Mayo Clinic health system Eau Claire, Eau Claire, WI; Division of Biomedical Statistics and I...

PURPOSE Recently, the authors showed that the inhibition of aldose reductase (AR) prevents bacterial endotoxin-induced uveitis in rats. They have now investigated the efficacy of AR inhibitors in the prevention of experimental autoimmune-induced uveitis (EAU) in rats. METHODS Lewis rats were immunized with bovine interphotoreceptor retinoid-binding peptide (IRBP) to develop EAU. Two or 8 days...