Multiple Sclerosisis (MS) is a common demylinating disease of CNS that inflammation and stress oxidative processes have an important role in clinical courses and progression of it. Suppressing the antigen-presenting capacity of glial cells seems a convinient way of reducing inflammatory activity in MS. The aim of the present study was to determine the anti-inflamatory effects of Melatonin on fa...

We obtained data from the French Ministry of Transport on all road crashes during 1994-8 (640 670) in which at least one person was severely injured (confirmed by paramedics) or died. Crashes were attended by police officers, who completed a standard ministry questionnaire that covered time of incident, location, road and weather conditions, vehicles involved, mechanical defects, health of driv...

OBJECTIVE To estimate fatigue during and after a multidisciplinary cardiac rehabilitation programme and its association with aerobic capacity. DESIGN Longitudinal cohort study. PATIENTS A total of 121 patients with coronary artery disease (79% men), mean age 57 years. METHODS Fatigue was measured with the Fatigue Severity Scale (FSS) and aerobic capacity with the 6-min walk test (6MWT). F...

NATO’s strategic transformation will have an important impact on the Alliance’s approach to the Mediterranean and on the future of its Mediterranean Initiative. During the Cold War, NATO’s strategy, doctrine, and military capabilities were oriented toward deterring a military threat from the Soviet Union. Today, the threats and challenges are more diverse—and more indirect. They range from ethn...

HIV disease progression is associated with declining quality of life and overall health status, although most research in this domain has been conducted among Western populations where B is the infecting clade. This study sought to determine the effects of early-stage clade-C HIV infection (CD4 count ≥400 cells/mm(3)) on neurocognitive functioning, cognitive depression, and fatigue by comparing...

OBJECTIVES To identify factors associated with poor physical function in rheumatoid arthritis and to assess whether baseline joint damage has an impact on improvement in physical function during infliximab treatment. METHODS 428 patients with active rheumatoid arthritis despite methotrexate treatment received methotrexate alone or with infliximab (3 mg/kg or 10 mg/kg every four or eight weeks...