The observation of an inter-attico-tympanic diaphragm in the middle ear (ME) cleft and the functional histology of the mucosa lead to a concept of ME morpho-functional partition. There are two separate compartments: an antero-inferior one, principally devoted to the muco-ciliary clearance function, and a postero-superior one, more devoted to the gas exchange function. With this concept of parti...

BACKGROUND The prevalence of repeated otitis media (OM) increased during the 1980s, but it is unknown if the increase has continued. OBJECTIVES To determine trends in the prevalence of OM, early-onset OM, and repeated OM among US children from 1988 to 1994 and to identify factors that may explain any observed changes. METHODS The Third National Health and Nutrition Examination Survey was ad...

ES-62 is the major secreted protein of the rodent filarial nematode Acanthocheilonema viteae. The molecule contains covalently attached phosphorylcholine (PC) residues, which confer anti-inflammatory properties on ES-62, underpinning the idea that drugs based on this active moiety may have therapeutic potential in human diseases associated with aberrant inflammation. Here we demonstrate that tw...

External ear canal cholesteatoma (EAC) is a rare destructive lesion within temporal bone and may occur in 1:1000 new patients with ear diseases [1, 3]. EAC cholesteatoma was first described by Toynbee in 1850. Since that time, it had confused to keratosis obturans. First description of keratosis obturans was presented by Piepergerdes et al., in 1980 [6]. Keratosis obturans (KO) is a similar to ...

BACKGROUND Chronic Otitis Media with effusion (COME) develops after sustained inflammation and is characterized by secretory middle ear epithelial metaplasia and effusion, most frequently mucoid. Non-typeable Haemophilus influenzae (NTHi), the most common acute Otitis Media (OM) pathogen, is postulated to promote middle ear epithelial remodeling in the progression of OM from acute to chronic. T...

The eosinophil-associated ribonuclease (Ear) family in the mouse consists of thirteen genes, eleven of which encode RNases that have physical/functional properties similar to the human Ears, eosinophil-derived neurotoxin and eosinophil cationic protein. The expression of Ear genes in the mouse is confined to sites of known eosinophilopoiesis, with the exception of the lung. Two Ear genes, Ear1 ...

Decanoic acid is used as an additive in injections to prolong the action of drugs because its lipid solubility. In addition, decanoic has been speculated have anti-inflammatory effects. this study, we examined effects on a mouse model dinitrofluorobenzene (DNFB)-induced irritant contact dermatitis. Mice were divided into four treatment groups. Groups 1, mice challenged with twice application 50...

DNA methylation is one of major epigenetic mechanisms by which regulate a panel gene expressions. An old but revisiting compound, 5-azacytidine, pyrimidine nucleoside analog cytidine that can inhibit methyltransferase, induce cell differentiation, and has direct cytotoxicity on abnormal bone marrow hematopoietic cells. Thus, systemic administration 5-azacytidine been approved for the treatment ...