The 9.5 MDa human pyruvate dehydrogenase complex (PDC) utilizes the specific dihydrolipoamide dehydrogenase (E3) binding protein (E3BP) to tether the essential E3 component to the 60-meric core of the complex. Here, we report crystal structures of the binding domain (E3BD) of human E3BP alone and in complex with human E3 at 1.6 angstroms and 2.2 angstroms, respectively. The latter structure sho...

Purpose: The initial development of conditionally replicative adenoviruses (CRAds) for cancer treatment has aimed at achieving selective replication in and killing of malignant cells. Other aspects such as the potentiation of the cytolytic capacity have also been investigated but still require new endeavors. As an extension of our prior work, we analyzed the effect of the E3 region, which inclu...

Although several studies have been reported on the synthesis of steroids in the fetus, the metabolism and conjugation of estrogens in the fetus is not completely known. In this study serum levels of estetrol (E4), estetrol glucosiduronate (E4-G), estriol (E3) and estriol-16-glucosiduronate (E3-16-G) were measured by R.I.A. in maternal peripheral vein blood (MPV), umbilical artery blood (UA) and...

We describe a method for generating sentences from “keywords” or “headwords”. This method consists of two main parts, candidate-text construction and evaluation. The construction part generates text sentences in the form of dependency trees by using complementary information to replace information that is missing because of a “knowledge gap” and other missing function words to generate natural ...