Granulocyte-macrophage colony-stimulating factor enhanced the efficacy of liposomal amphotericin B (LAMB) in a murine model of disseminated infection by Rhizopus oryzae, significantly prolonging survival and reducing tissue burden. The use of gamma interferon (IFN-gamma) alone was ineffective, and IFN-gamma combined with LAMB did not improve the results obtained with LAMB alone.

As applied by Bethe, Brown, and Stehn in 1950, the first theory of the Lamb shift, although it contains many physical and mathematical approximations, is known to be in agreement with experiment (tens of MHz discrepancies). In the present work, thanks to new analytic formulas and computer means, we perform their original method of calculation again, without two approximations in the contributio...

The survival probability, S N (t), of a diiusing prey (\lamb") in the proximity of N diiusing predators (a \pride of lions") in one dimension is investigated. When the lions are all to one side of the lamb, the survival probability decays as a non-universal power law, S N (t) / t ? N , with the decay exponent N proportional to ln N. The crossover behavior as a function of the relative diiusivit...

The survival probability, S N (t), of a diffusing prey (" lamb ") in the proximity of N diffusing predators (a " pride of lions ") in one dimension is investigated. When the lions are all to one side of the lamb, the survival probability decays as a non-universal power law, S N (t) ∝ t −β N , with the decay exponent β N proportional to ln N. The crossover behavior as a function of the relative ...

Cryptococcal meningoencephalitis is a rapidly lethal infection in immunocompromised patients. Induction regimens are usually administered for 2 weeks. The shortest effective period of induction therapy with liposomal amphotericin B (LAMB) is unknown. The pharmacodynamics of LAMB were studied in murine and rabbit models of cryptococcal meningoencephalitis. The concentrations of LAMB in the plasm...

OBJECTIVE To investigate if combination therapy with liposomal amphotericin B (LAmB), and caspofungin (CAS) is superior to monotherapies in an experimental model with azole-resistant Candida albicans. METHODS This study was carried out between October 2006 and August 2007 in Celal Bayar University, Manisa, Turkey. A total of 144 mice were included in the study, and divided into 4 groups as: c...

Direct and maternal components of variance for lamb survival to birth, 7 d, and weaning (110 d) were estimated by REML procedures in a flock of Australian Merino sheep. A total of 14,142 lambs, the progeny of 421 sires and 3,666 dams, born between 1975 and 1983 were available for analysis. The study has produced some of the most precise estimates of genetic parameters for lamb survival in the A...

Four Aspergillus nidulans genes are known to be under the control of the trans-acting regulatory gene amdR. We describe the isolation and initial characterization of one of these amdR-regulated genes, lamA. The lam locus, however, was found to consist of two divergently transcribed genes, the lamA gene, and a new gene, also under amdR control, which we have designated lamB. Using recombinant DN...

The purpose of this study was to identify and compare the different evaluations made by the agents at either end of the lamb meat chain, i.e. producers and consumers, in relation to the parameters that consumers use when purchasing lamb meat and the factors that affect the production of quality lamb meat. In addition, consumer segments that can be targeted for action by the different agents in ...

B13, one of the immunodominant antigens of Trypanosoma cruzi, is composed of repeats of a 12-amino-acid motif. Using synthetic peptides, the sequence FGQAAAGDK was previously shown to contain the B13 immunodominant epitope recognized by chagasic patients sera. To investigate the effects of neighboring sequences in the immunodominance, we tested serum recognition of two B13 sequences fused to La...