The cost-effectiveness of combination therapy with an α1 blocker and dutasteride in benign prostatic hyperplasia (BPH) was analyzed in comparison with α1 blocker monotherapy. A Markov model with seven health states related to BPH was constructed with 4-year and 10-year time horizons and from the entire payers perspective. The transition probabilities among different health states input into the...

AIM we aimed to systematically review drugs to treat lower urinary tract symptoms (LUTS) regularly used in older persons to classify appropriate and inappropriate drugs based on efficacy, safety and tolerability by using the Fit fOR The Aged (FORTA) classification. METHODS to evaluate the efficacy, safety and tolerability of drugs used for treatment of LUTS in older persons, a systematic revi...

Prostate cancer management has focused on early detection and treatment, but the prolonged development cycle of prostate cancer suggests that prevention may be a preferable approach. Finasteride and dutasteride, inhibitors of 5 -reductase, inhibit conversion of testosterone to dihydrotestosterone (a potent androgen) and have low toxicity, which makes them attractive chemopreventive agents. Both...

Using an antibody against 5α-reduced neurosteroids, predominantly allopregnanolone, we found that immunostaining in the CA1 region of rat hippocampal slices was confined to pyramidal neurons. This neurosteroid staining was increased following 15 min administration of 60 mm but not 20 mm ethanol, and the enhancement was blocked by finasteride and dutasteride, selective inhibitors of 5α-reductase...

The Eighth Annual Frontiers in Cancer Prevention Research meeting was held in Houston, Texas, in November 2009. This report highlights significant presentations that advance the fields of chemoprevention, clinical trial recruitment and retention, cancer screening including optical imaging, energy balance, and nutritional epidemiology, and health communications and decision making. In findings f...

BACKGROUND Studies suggest that obesity is associated with lower risk of prostate cancer but more aggressive cancers. As obesity lowers PSA levels, these observations may be influenced by detection bias. We examined the association between obesity and risk of low- and high-grade prostate cancer in REDUCE, in which biopsies were largely independent of PSA. METHODS The REDUCE study tested dutas...

Androgenetic alopecia is a medical condition with deep social and psychological impact on the affected individuals characterized by progressive hair thinning, leading to loss over scalp in both males females. Minoxidil oral form primarily an antihypertensive drug, whose mechanism of action not completely known. Dutasteride 5-alpha reductase inhibitor, acting alpha-1 alpha-2 receptors. The autho...

To the Editor: We read with great interest an observational study titled “Effectiveness of dutasteride in a large series patients frontal fibrosing alopecia real clinical practice” by Pindado-Ortega et al,1Pindado-Ortega C. Saceda-Corralo D. Moreno-Arrones O.M. al.Effectiveness practice.J Am Acad Derm. 2020; 84: 1285-1294Abstract Full Text PDF PubMed Scopus (7) Google Scholar another important ...

Today the problem of treatment patients with benign prostatic hyperplasia (BPH) is actual one. BPH an age-related chronic progressive disease. It especially relevant for men over age 50 years. According to WHO demographic data, world’s population becoming older, so incidence going increase, that leads a significant decline in quality life due dysfunction lower urinary tract and presence symptom...