BACKGROUND Helicobacter pylori affects gastric epithelium integrity by acceleration of apoptosis. However, it remains unclear what product of the bacteria causes apoptosis, or whether or not the apoptosis is involved in the development of ulcers. AIMS To elucidate the factor from H pylori that causes acceleration of apoptosis and the role of apoptosis in the development of duodenal ulcer in H...

Background: Although exenatide is a valuable option of treatments for type 2 diabetes (T2DM) in obese patients, mild to moderate nausea or vomiting in a usual dose of administration is most common. The adverse event usually decreases with time. Methods and Results: A case of 58-year-old female with T2DM and gastric ulcers is reported. Before treatment with exenatide, she had hemoglobin A1c (NGS...

A study was conducted to see whether patients with duodenal ulcers that failed to heal in response to H2 receptor antagonists had a higher incidence of recurrent ulceration after highly selective vagotomy than patients whose ulcers healed with these drugs. Between 1977 and 1983, 157 patients had a highly selective vagotomy for uncomplicated duodenal ulcer; in 57 patients the ulcer had failed to...

Difficulty in excluding duodenal ulceration by standard radiology has hampered investigation of duodenitis; endoscopy and biopsy add a new dimension. We have studied 51 patients with dyspeptic symptoms or bleeding in whom endoscopy revealed congested and irregular areas of duodenal bulb mucosa in the absence of ulcer or scar. Biopsy revealed unequivocal active inflammation-epithelial cell atypi...

Use of anticholinergic drugs in treatment of duodenal ulcers is limited by the side effects of widespread parasympathetic blockade evoked by usual therapeutic doses. A study. was conducted into the effectiveness of transdermal delivery of hyoscine methobromide using a new system which releases the drug into the circulation at a controlled rate. In six patients whose duodenal ulcer had healed se...

Peptic ulceration was thought to be rare in Nigerians until the 1930s when Aitken (1933) and Rose (1935) reported on this condition. Chronic duodenal ulcers, in particular, are being reported with increasing frequency (Ellis, 1948; Konstam, 1959). The symptoms and complications of duodenal ulcers in Nigerians are the same as elsewhere, but the relative incidence of these complications differs m...

From 1966 to 1985, 2130 patients with gastric cancer were admitted to our surgical department. Among these cancers, gastric cancer following partial gastrectomy for benign gastroduodenal lesion were present in 22 (1%) patients. The original pathology was gastric ulcers in 64% (14 patients), duodenal ulcers in 23% (5 patients), combined gastric and duodenal ulcers in 9% (2 patients), and leiomyo...

The effect of combined treatment with sulpiride plus cimetidine was compared against that of cimetidine alone on the healing of duodenal ulcer and on the subsequent relapse rate. In a double blind study, 35 patients with duodenal ulcer diagnosed by endoscopy were randomly assigned to receive cimetidine 800 mg daily and 38 patients to receive cimetidine 800 mg plus sulpiride 200 mg daily. Sixty ...

Introduction An ulcer is a sore or lesion that forms in the lining of the stomach or duodenum where acid and pepsin are present. Ulcers in the stomach are called gastric or stomach ulcers. Those in the duodenum are called duodenal ulcers. In general, ulcers in the stomach and duodenum are referred to as peptic ulcers. Ulcers occur in the esophagus or in the first portion of the duodenum, the du...

Estimates of the population prevalence of peptic and duodenal ulceration in men aged between 25 and 64 years were made in the London borough of Lambeth. The sampling frame for these estimates was a 20% private census. The lifetime prevalence rate of proved peptic ulcer (haematemesis, gastric and duodenal ulcers as validated by operation or barium meal), adjusted for age and social class, was es...